2-Naphthalen-2-ylsulfonyl-3a,4-dihydroimidazo[1,5-a]indole-1,3-dione | 769926-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Naphthalen-2-ylsulfonyl-3a,4-dihydroimidazo[1,5-a]indole-1,3-dione
• CAS: 769926-06-9
• 化学式: C₂₀H₁₄N₂O₄S
• 分子量: 378.408
• InChiKey: HCCUXWCDNCLIBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吲哚啉-2-羧酸 在 盐酸 、 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 15.0h， 生成 2-Naphthalen-2-ylsulfonyl-3a,4-dihydroimidazo[1,5-a]indole-1,3-dione
  参考文献：
  名称：

  Design, synthesis and biological evaluation of new thalidomide analogues as TNF-α and IL-6 production inhibitors

  摘要：

  Several thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cells (PBMCs). Among these compounds, two analogues containing sulfonyl group displayed interesting downregulation of TNF-alpha and IL-6 production. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.031

文献信息

• Design, synthesis and biological evaluation of new thalidomide analogues as TNF-α and IL-6 production inhibitors
  作者：Charlotte Chaulet、Cécile Croix、David Alagille、Sylvain Normand、Adriana Delwail、Laure Favot、Jean-Claude Lecron、Marie-Claude Viaud-Massuard

  DOI：10.1016/j.bmcl.2010.12.031

  日期：2011.2

  Several thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 by LPS-activated peripheral blood mononuclear cells (PBMCs). Among these compounds, two analogues containing sulfonyl group displayed interesting downregulation of TNF-alpha and IL-6 production. (C) 2010 Elsevier Ltd. All rights reserved.