1-O,O-diethylphosphonyl-1-cyclopropanecarboxylic acid | 108168-62-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 1-O,O-diethylphosphonyl-1-cyclopropanecarboxylic acid
• 英文别名: 1-(Diethoxyphosphoryl)cyclopropanecarboxylic acid；1-diethoxyphosphorylcyclopropane-1-carboxylic acid
• CAS: 108168-62-3
• 化学式: C₈H₁₅O₅P
• mdl: MFCD01306200
• 分子量: 222.178
• InChiKey: SGMINOGKRUHAHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-carbethoxy-1-O,O-diethylphosphonylcyclopropane 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以35%的产率得到1-O,O-diethylphosphonyl-1-cyclopropanecarboxylic acid
  参考文献：
  名称：

  Cycloalkylation of compounds in the series of phosphorus-substituted derivatives of acetic acid

  摘要：

  1-Phosphoryl-substituted cyclopropanes, cyclobutanes, and cyclopentanes were obtained by the reaction of phosphoryl-substituted esters and nitriles of acetic acid with alpha,omega-dihaloalkanes. The influence of the CH-acidity of the starting compounds and electrophilicity of the alkylating agent on the reaction rate was examined.

  DOI：

  10.1007/bf00961505

文献信息

• KAZAKOV, P. V.;ODINETS, I. L.;LARETINA, A. P.;SHCHERBINA, T. M.;PETROVSKI+, IZV. AN CCCP. CEP. XIM.,(1990) N, S. 1873-1880
  作者：KAZAKOV, P. V.、ODINETS, I. L.、LARETINA, A. P.、SHCHERBINA, T. M.、PETROVSKI+

  DOI：——

  日期：——
• Cycloalkylation of compounds in the series of phosphorus-substituted derivatives of acetic acid
  作者：P. V. Kazakov、I. L. Odinets、A. P. Laretina、T. M. Shcherbina、P. V. Petrovskii、L. V. Kovalenko、T. A. Mastryukova

  DOI：10.1007/bf00961505

  日期：1990.8

  1-Phosphoryl-substituted cyclopropanes, cyclobutanes, and cyclopentanes were obtained by the reaction of phosphoryl-substituted esters and nitriles of acetic acid with alpha,omega-dihaloalkanes. The influence of the CH-acidity of the starting compounds and electrophilicity of the alkylating agent on the reaction rate was examined.