(Z)-3,3′-[1,2-dimethyl-1,2-ethenediyl]bisphenol | 133633-62-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (Z)-3,3′-[1,2-dimethyl-1,2-ethenediyl]bisphenol
• 英文别名: (Z)-3,3'-[1,2-dimethyl-1,2-ethenediyl]bisphenol；3-[(Z)-3-(3-hydroxyphenyl)but-2-en-2-yl]phenol
• CAS: 133633-62-2
• 化学式: C₁₆H₁₆O₂
• 分子量: 240.302
• InChiKey: LZVBSFWOSQFAFL-QXMHVHEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-羟基苯乙酮 在 四氯化钛 、 锌 作用下， 以 四氢呋喃 为溶剂， 以60%的产率得到
  参考文献：
  名称：

  Compositions and methods for adipocyte modulation

  摘要：

  提供了改性的苯乙烯类化合物及其制剂。改性苯乙烯类化合物可以包括一个或多个氨基或氨基烷基取代基。该制剂可用于治疗或预防肥胖症，并且改性苯乙烯类化合物以有效量存在，以缓解或预防肥胖症的一个或多个症状。提供了制备改性苯乙烯类化合物及其制剂的方法。提供了使用有效量的改性苯乙烯类化合物治疗受试者，以缓解或预防与糖尿病、心血管疾病、高血压、深静脉血栓、骨关节炎、阻塞性睡眠呼吸暂停、癌症和非酒精性脂肪肝病等相关的一个或多个症状的方法。改性苯乙烯类化合物的给药可以导致PKCδII、PKCδVIII的水平降低，PKCδI的表达基本不变；脂肪细胞数量减少；体重和/或脂肪减少增加；或其组合。

  公开号：

  US09458086B1

文献信息

• Compositions and methods for adipocyte modulation
  申请人：Patel Niketa A.

  公开号：US09458086B1

  公开（公告）日：2016-10-04

  Modified stilbenoids and formulations thereof are provided. The modified stilbenoids can include one or more amino or amino-alkyl substituents. The formulation can be for the treatment or prevention of obesity and the modified stilbenoid present in an effective amount to alleviate or prevent the onset of one or more symptoms of obesity. Methods of making the modified stilbenoids and formulations thereof are provided. Methods are provided for treating a subject with a modified stilbenoid in an effective amount to alleviate or prevent one or more symptoms associated with diabetes, cardiovascular disease, high blood pressure, deep vein thrombosis, osteoarthritis, obstructive sleep apnea, cancer, and non-alcoholic fatty liver disease. The administration of the modified stilbenoids can result in decreased levels of PKCδII, PKCδVIII, substantially unaltered expression of PKCδI; a decreased number of adipocytes; increased weight and/or fat loss; or a combination thereof.

  提供了改性的苯乙烯类化合物及其制剂。改性苯乙烯类化合物可以包括一个或多个氨基或氨基烷基取代基。该制剂可用于治疗或预防肥胖症，并且改性苯乙烯类化合物以有效量存在，以缓解或预防肥胖症的一个或多个症状。提供了制备改性苯乙烯类化合物及其制剂的方法。提供了使用有效量的改性苯乙烯类化合物治疗受试者，以缓解或预防与糖尿病、心血管疾病、高血压、深静脉血栓、骨关节炎、阻塞性睡眠呼吸暂停、癌症和非酒精性脂肪肝病等相关的一个或多个症状的方法。改性苯乙烯类化合物的给药可以导致PKCδII、PKCδVIII的水平降低，PKCδI的表达基本不变；脂肪细胞数量减少；体重和/或脂肪减少增加；或其组合。
• KINASE INHIBITOR COMPOUNDS
  申请人：Sayeski Peter P.

  公开号：US20110301159A1

  公开（公告）日：2011-12-08

  The disclosure relates to novel compounds that are capable of modulating Jak2 kinase activities, compounds that have therapeutic use in treating or preventing a subject suffering from or susceptible to a Jak2 mediated disease or disorder, and methods of use and compositions thereof.
• VIMENTIN AS A BIOMARKER FOR THE PROGRESSION OF MYELOPROLIFERATIVE NEOPLASMS
  申请人：University of Florida Research Foundation

  公开号：US20140248634A1

  公开（公告）日：2014-09-04

  The disclosure relates to novel compounds that are capable of modulating Jak2 kinase activities, compounds that have therapeutic use in treating or preventing a subject suffering from or susceptible to a Jak2 mediated disease or disorder, and methods of use and compositions thereof.
• [EN] KINASE INHIBITOR COMPOUNDS<br/>[FR] COMPOSÉS INHIBITEURS DE KINASE
  申请人：UNIV FLORIDA

  公开号：WO2010068710A2

  公开（公告）日：2010-06-17

  The disclosure relates to novel compounds that are capable of modulating Jak2 kinase activities, compounds that have therapeutic use in treating or preventing a subject suffering from or susceptible to a Jak2 mediated disease or disorder, and methods of use and compositions thereof.
• [EN] VIMENTIN AS A BIOMARKER FOR THE PROGRESSION OF MYELOPROLIFERATIVE NEOPLASMS<br/>[FR] UTILISATION DE LA VIMENTINE COMME BIOMARQUEUR DE L'ÉVOLUTION DES NÉOPLASMES MYÉLOPROLIFÉRATIFS
  申请人：UNIV FLORIDA

  公开号：WO2013019655A2

  公开（公告）日：2013-02-07

  The disclosure relates to novel compounds that are capable of modulating Jak2 kinase activities, compounds that have therapeutic use in treating or preventing a subject suffering from or susceptible to a Jak2 mediated disease or disorder, and methods of use and compositions thereof.