2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl (E)-but-2-enoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl (E)-but-2-enoate
• 化学式: C₁₂H₁₅N₅O₄
• 分子量: 293.28
• InChiKey: FZPBBAJCCXWZQY-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• MEDICAMENT FOR TREATING PERIPHERAL NEUROPATHIES
  申请人：Hsiao Lily

  公开号：US20140213600A1

  公开（公告）日：2014-07-31

  The invention provides a method for treatment of the diseases in a human by identifying the human as one suffering from a herpes simplex virus (HSV), and then administering to the human the compound anti-HSV agent or a pharmaceutically acceptable salt thereof. The diseases include dermatosis and non-dermatosis, wherein the dermatosis include acnes, impetigo, pyoderma gangrenosum, chilblains and psoriasiform, asteatotic dermatitis, ichthyosis, lichen simplex chronicus (Neurodermatitis, Prurigo), seborrhoeic dermatitis, rosacea, perioral dermatitis, epidermal cyst, wound ulcer, discoid lupus erythematosus, vitiligo, Alopecia, diagnostic criteria of some autoimmune diseases such as systemic lupus erythematosus or diabetic skin complications, wherein the non-dermatosis include glomerulonephritis, arthritis, Crohn's disease, ulcerative colitis, myelodysplasia, multiple myeloma, demyelinating disease, Parkison's disease, anemia, cytopenia those among the diagnostic criteria.
• Medicament for Treating Peripheral Neuropathies
  申请人：Hsiao Lily

  公开号：US20180193348A1

  公开（公告）日：2018-07-12

  The invention provides a pharmaceutical composition for treating atopic dermatitis of a human that is induced by Herpes simplex virus (HSV), said pharmaceutical composition comprising an effective amount of 2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]ethyl-2-amino-3-methylbutanoate and an effective amount of an Anti-allergic agent.
• US9526729B2
  申请人：——

  公开号：US9526729B2

  公开（公告）日：2016-12-27