Furan-2-carboxylic acid morpholin-4-ylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: Furan-2-carboxylic acid morpholin-4-ylamide
• 英文别名: N-morpholin-4-ylfuran-2-carboxamide
• 化学式: C₉H₁₂N₂O₃
• mdl: MFCD01413211
• 分子量: 196.206
• InChiKey: ZWUROWZCQQHVIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.444
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 Furan-2-carboxylic acid morpholin-4-ylamide 在 四甲基乙二胺 、 仲丁基锂 作用下， 以 四氢呋喃 为溶剂， 生成 3-Trimethylsilanyl-furan-2-carboxylic acid morpholin-4-ylamide 、 5-Trimethylsilanyl-furan-2-carboxylic acid morpholin-4-ylamide
  参考文献：
  名称：

  Dialkylhydrazides for directed orthometalations

  摘要：

  Dimethylhydrazides are shown to be excellent substrates for the directed orthometalation reaction. The advantage of using the hydrazide is that it is easily removed by treatment with H5IO6 or CuCl2 to give the carboxylic acid under very mild conditions, in contrast to other amides that generally require harshly acidic conditions to achieve hydrolysis. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00462-7

文献信息

• Dialkylhydrazides for directed orthometalations
  作者：Scott A Pratt、Michael P Goble、Michael J Mulvaney、Peter G.M Wuts

  DOI：10.1016/s0040-4039(00)00462-7

  日期：2000.5

  Dimethylhydrazides are shown to be excellent substrates for the directed orthometalation reaction. The advantage of using the hydrazide is that it is easily removed by treatment with H5IO6 or CuCl2 to give the carboxylic acid under very mild conditions, in contrast to other amides that generally require harshly acidic conditions to achieve hydrolysis. (C) 2000 Elsevier Science Ltd. All rights reserved.