3,7-bis(azetidin-1-yl)-1,9-dichloro-10H-phenothiazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3,7-bis(azetidin-1-yl)-1,9-dichloro-10H-phenothiazine
• 化学式: C₁₈H₁₇Cl₂N₃S
• 分子量: 378.3
• InChiKey: ASXSJYAGNBMETN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING ALZHEIMER'S DISEASE
  申请人：Prosetta Antiviral Inc.

  公开号：US20140315897A1

  公开（公告）日：2014-10-23

  Novel methods and compounds for treating Alzheimer's Disease are provided. In one aspect, the invention provides methods for treating Alzheimer's Disease by administering certain phenothiazine derivatives. In one embodiment, the methods include administering an effective amount of a 3-oxo-7-dialkyl-amino-phenothiazine derivative, or 3-oxo-7-dialkyl-amino-phenothiazine. In another embodiment, the invention provides methods for treating Alzheimer's Disease by administering an effective amount of a 3,7-diazetidin-1-yl-phenothiazine or a derivative thereof. In another aspect, the invention provides novel azetidinyl phenothiazine compounds.

  本发明提供了治疗阿尔茨海默病的新方法和化合物。在一个方面，本发明提供了通过给予某些苯并噻嗪衍生物治疗阿尔茨海默病的方法。在一个实施例中，该方法包括给予有效量的3-氧代-7-二烷基氨基苯并噻嗪衍生物或3-氧代-7-二烷基氨基苯并噻嗪。在另一个实施例中，本发明提供了通过给予有效量的3,7-二氮杂-1-基苯并噻嗪或其衍生物治疗阿尔茨海默病的方法。在另一个方面，本发明提供了新的氮杂环苯并噻嗪化合物。
• Compounds, Compositions, and Methods for Treating Alzheimer's Disease
  申请人：Prosetta Antiviral Inc.

  公开号：US20170151253A1

  公开（公告）日：2017-06-01

  Novel methods and compounds for treating Alzheimer's Disease are provided. In one aspect, the invention provides methods for treating Alzheimer's Disease by administering certain phenothiazine derivatives. In one embodiment, the methods include administering an effective amount of a 3-oxo-7-dialkyl-amino-phenothiazine derivative, or 3-oxo-7-dialkyl-amino-phenothiazine. In another embodiment, the invention provides methods for treating Alzheimer's Disease by administering an effective amount of a 3,7-diazetidin-1-yl-phenothiazine or a derivative thereof. In another aspect, the invention provides novel azetidinyl phenothiazine compounds.
• US8796448B1
  申请人：——

  公开号：US8796448B1

  公开（公告）日：2014-08-05
• US9382221B2
  申请人：——

  公开号：US9382221B2

  公开（公告）日：2016-07-05