N-[1-[(2R,3R,4R,5S)-3-fluoro-5-(hydroxymethyl)-3,4-dimethyloxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: N-[1-[(2R,3R,4R,5S)-3-fluoro-5-(hydroxymethyl)-3,4-dimethyloxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
• 化学式: C₁₈H₂₀FN₃O₄
• 分子量: 361.4
• InChiKey: OBUCYNYODNUOOP-MAAOGQSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  91.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 5'-SUBSTITUTED NUCLEOSIDE ANALOGS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Verma Vishal A.

  公开号：US20140221304A1

  公开（公告）日：2014-08-07

  The present invention relates to 5′-Substituted Nucleoside Analogs of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, Z, R 1 , R 2 , R 3 and R 3′ are as defined herein. The present invention also relates to compositions comprising at least one 5′-Substituted Nucleoside Analog, and methods of using the 5′-Substituted Nucleoside Analogs for treating or preventing HCV infection in a patient.
• US9408863B2
  申请人：——

  公开号：US9408863B2

  公开（公告）日：2016-08-09