6-[[3-[[1-[4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]amino]-3-oxopropyl]disulfanyl]hexanoic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 6-[[3-[[1-[4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]amino]-3-oxopropyl]disulfanyl]hexanoic acid
• 英文别名: 6-[[3-[[1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]amino]-3-oxopropyl]disulfanyl]hexanoic acid
• 化学式: C₁₈H₂₇N₃O₇S₂
• 分子量: 461.6
• InChiKey: JCPIEVPWFXTENU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  199
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Methods and apparatus for synthesizing nucleic acids
  申请人：Molecular Assemblies, Inc.

  公开号：US10041110B2

  公开（公告）日：2018-08-07

  The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template. Because the nucleotide analogs have an unmodified 3′ OH, i.e., as found in “natural” deoxyribose and ribose molecules, the analogs result in natural polynucleotides suitable for incorporation into biological systems.

  本发明提供了使用酶和专门设计的核苷酸类似物合成多核苷酸（如 DNA 和 RNA）的改进方法。使用本发明的方法，可以在水环境中逐个碱基地从头合成特定序列的多核苷酸，而无需使用核酸模板。由于核苷酸类似物具有未修饰的 3′OH，即 "天然 "脱氧核糖和核糖分子中的 3′OH，因此类似物产生的天然多核苷酸适合加入生物系统中。
• Reusable initiators for synthesizing nucleic acids
  申请人：Molecular Assemblies, Inc.

  公开号：US10683536B2

  公开（公告）日：2020-06-16

  The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.

  本发明提供了使用与固体支持物耦合的可再生引发剂合成多核苷酸（如 DNA 和 RNA）的改进方法。使用本发明的方法，可以在水环境中逐个碱基从头合成特定序列的多核苷酸，而无需使用核酸模板。
• METHODS AND APPARATUS FOR SYNTHESIZING NUCLEIC ACIDS
  申请人：Molecular Assemblies, Inc.

  公开号：US20140363852A1

  公开（公告）日：2014-12-11

  The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template. Because the nucleotide analogs have an unmodified 3′ OH, i.e., as found in “natural” deoxyribose and ribose molecules, the analogs result in natural polynucleotides suitable for incorporation into biological systems.
• METHODS AND APPARATUS FOR SYNTHESIZING NUCLEIC ACID
  申请人：MOLECULAR ASSEMBLIES, INC.

  公开号：US20160046973A1

  公开（公告）日：2016-02-18

  The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template. Because the nucleotide analogs have an unmodified 3′ OH, i.e., as found in “natural” deoxyribose and ribose molecules, the analogs result in natural polynucleotides suitable for incorporation into biological systems.
• REUSABLE INITIATORS FOR SYNTHESIZING NUCLEIC ACIDS
  申请人：MOLECULAR ASSEMBLIES, INC.

  公开号：US20160046974A1

  公开（公告）日：2016-02-18

  The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.