N-[1-[(2R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]propanamide

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: N-[1-[(2R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]propanamide
• 化学式: C₁₂H₁₅F₂N₃O₅
• 分子量: 319.26
• InChiKey: AXIPNTCZPYZEHZ-YRXSASNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• GEMCITABINE AMIDE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF
  申请人：Song Yunlong

  公开号：US20140235568A1

  公开（公告）日：2014-08-21

  The present invention relates to the field of medical technology, and in particular relates to a kind of gemcitabine amide derivative with a novel structure. The new compounds of the present invention are very active with regard to many tumour cells such as human lung cancer, colon cancer, breast cancer and liver cancer etc., and therefore can be used for preparing anti-tumour drugs. In addition, these compounds also have anti-viral activity. Also disclosed are a preparation method for the compounds, a pharmaceutical composition containing the compounds and the use thereof in preparing drugs against tumours and viruses etc.

  本发明涉及医疗技术领域，具体涉及一种具有新颖结构的吉西他滨酰胺衍生物。本发明的新化合物对人类肺癌、结肠癌、乳腺癌和肝癌等多种肿瘤细胞具有很高的活性，因此可用于制备抗肿瘤药物。此外，这些化合物还具有抗病毒活性。还公开了这些化合物的制备方法、含有这些化合物的药物组合物以及它们在制备抗肿瘤和抗病毒药物等方面的用途。