[EN] SPIROCYCLIC MOLECULES AS MTH1 INHIBITORS<br/>[FR] MOLÉCULES SPIROCYCLIQUES SERVANT D'INHIBITEURS DE MTH1
申请人:WANG ZHAOYIN
公开号:WO2015172747A1
公开(公告)日:2015-11-19
Disclosed are spirocyclic compounds having MTH1 inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are useful for the treatment of abnormal cell growth, such as cancers.
[1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUND AS JAK INHIBITOR AND USE THEREOF
申请人:Zhuhai United Laboratories Co., Ltd.
公开号:US20210155621A1
公开(公告)日:2021-05-27
Disclosed are a [1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and an application thereof in preparing a drug for treating a disease related to JAK or/and TYK2. Specifically, the present invention relates to a compound represented by formula (I), or an isomer or pharmaceutically acceptable salt thereof. (I)
SPIROCYCLIC MOLECULES AS PROTEIN KINASE INHIBITORS
申请人:Wang Zhaoyin
公开号:US20140243303A1
公开(公告)日:2014-08-28
The present invention relates to spirocyclic compounds of formula I, namely spirocyclic (1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fiuorophenyl)ethoxy)pyridin-2-amines having protein kinase inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are c-Met and/or ALK inhibitors useful for the treatment of abnormal cell growth, such as cancers.
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USE OF JAK INHIBITORS IN PREPARATION OF DRUGS FOR TREATING JAK KINASE-RELATED DISEASES
申请人:Zhuhai United Laboratories Co., Ltd
公开号:EP4105214A1
公开(公告)日:2022-12-21
The invention discloses an application of JAK inhibitors [1,2,4]triazolo[1,5-a]pyridine compounds in the preparation and treatment of autoimmune, inflammatory or allergic diseases, transplantation rejection and other diseases. The JAK inhibitors [1,2,4]triazolo[1,5-a]pyridine compounds include the compounds shown in formula (I), their isomers or their pharmaceutically acceptable salts:
the JAK inhibitors of the present invention have good efficacy in animal model tests of autoimmune, inflammatory or allergic diseases, especially in animal in vivo efficacy evaluation tests of inflammatory bowel disease and allergic dermatitis.
[EN] ORAL PREPARATION CONTAINING JAK INHIBITOR OR SALT THEREOF OR CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF<br/>[FR] PRÉPARATION ORALE CONTENANT UN INHIBITEUR DE JAK OU UN SEL DE CELUI-CI OU UNE FORME CRISTALLINE DE CELUI-CI, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION<br/>[ZH] 一种含有JAK抑制剂或其盐或其晶型的口服制剂及其制备方法和应用