[(2R,6S,16E,18E,20S,21S)-11-chloro-21-hydroxy-12,20-bis(hydroxymethyl)-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl] (2S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: [(2R,6S,16E,18E,20S,21S)-11-chloro-21-hydroxy-12,20-bis(hydroxymethyl)-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl] (2S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate
• 化学式: C₃₅H₄₈ClN₃O₁₀S
• 分子量: 738.3
• InChiKey: VLMFULLDNHOSJC-MKEDSVPWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  50
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  180
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• Anti-CD33 antibodies and methods for treatment of acute myeloid leukemia using the same
  申请人：IMMUNOGEN INC.

  公开号：US10000566B2

  公开（公告）日：2018-06-19

  The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced versions of these antibodies, functional equivalents and improved versions of these antibodies, immunoconjugates and compositions comprising these antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding these antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing these antibodies.

  本发明涉及结合 CD33 的抗体。更具体地说，本发明涉及抗 CD33 抗体、这些抗体的片段和同源物、这些抗体的人源化和复合物、这些抗体的功能等效物和改进型、包含这些抗体的免疫结合剂和组合物，以及这些抗体在诊断、研究和治疗中的应用。本发明还涉及编码这些抗体的多核苷酸、包含多核苷酸的载体、用多核苷酸转化的宿主细胞以及生产这些抗体的方法。
• ANTI-CD33 ANTIBODIES AND METHODS FOR TREATMENT OF ACUTE MYELOID LEUKEMIA USING THE SAME
  申请人：IMMUNOGEN INC.

  公开号：US20140248267A1

  公开（公告）日：2014-09-04

  The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced versions of these antibodies, functional equivalents and improved versions of these antibodies, immunoconjugates and compositions comprising these antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding these antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing these antibodies.
• US9359442B2
  申请人：——

  公开号：US9359442B2

  公开（公告）日：2016-06-07