[(2R,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[3-[(5-amino-5-oxopentan-2-yl)disulfanyl]propanoyl-methylamino]propanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: [(2R,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[3-[(5-amino-5-oxopentan-2-yl)disulfanyl]propanoyl-methylamino]propanoate
• 化学式: C₄₀H₅₇ClN₄O₁₁S₂
• 分子量: 869.5
• InChiKey: RILOTCQNRZRBDI-RDXUCAITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  58
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  250
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• ANTI-CD33 ANTIBODIES AND METHODS FOR TREATMENT OF ACUTE MYELOID LEUKEMIA USING THE SAME
  申请人：IMMUNOGEN INC.

  公开号：US20140248267A1

  公开（公告）日：2014-09-04

  The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced versions of these antibodies, functional equivalents and improved versions of these antibodies, immunoconjugates and compositions comprising these antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding these antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing these antibodies.
• US9359442B2
  申请人：——

  公开号：US9359442B2

  公开（公告）日：2016-06-07