5-hydroxy-1-[(2R,4S,5R)-4-methoxy-5-(methoxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-hydroxy-1-[(2R,4S,5R)-4-methoxy-5-(methoxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 化学式: C₁₁H₁₆N₂O₆
• 分子量: 272.25
• InChiKey: CIGZBEKNAMNQCF-DJLDLDEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  97.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Nucleic acid compounds for binding growth differentiation factor 8
  申请人：SOMALOGIC, INC.

  公开号：US10370669B2

  公开（公告）日：2019-08-06

  Described herein are aptamers capable of binding to growth differentiation factor 8 (GDF8) protein; compositions comprising a GDF8 binding aptamer; and methods of making and using the same.

  本文描述了能够与生长分化因子 8（GDF8）蛋白结合的适配体；包含 GDF8 结合适配体的组合物；以及制造和使用这些适配体的方法。
• Multiaptamer target detection
  申请人：SomaLogic, Inc.

  公开号：US10392621B2

  公开（公告）日：2019-08-27

  Described herein are compositions comprising a first aptamer, second aptamer and a target that are capable of forming a ternary complex, and wherein the first aptamer and the second aptamer comprise C-5 pyrimidine modification schemes that are different, and methods of making and using such compositions.

  本文描述的是包含能够形成三元复合物的第一适配体、第二适配体和靶标的组合物，其中第一适配体和第二适配体包含不同的 C-5 嘧啶修饰方案，以及制造和使用这种组合物的方法。
• Nucleic acid compounds for binding growth differentiation factor 11
  申请人：SomaLogic Operating Co., Inc.

  公开号：US11535852B2

  公开（公告）日：2022-12-27

  Described herein are aptamers capable of binding to growth differentiation factor 11 (GDF11) protein; compositions comprising a GDF11 binding aptamer with a GDF11 protein; and methods of making and using the same.

  本文描述了能够与生长分化因子 11（GDF11）蛋白结合的适配体；包含 GDF11 结合适配体与 GDF11 蛋白的组合物；以及制造和使用这些组合物的方法。
• APTAMERS TO ß-NGF AND THEIR USE IN TREATING ß-NGF MEDIATED DISEASES AND DISORDERS
  申请人：Somalogic, Inc.

  公开号：EP2558586B1

  公开（公告）日：2016-10-12
• Multiplexed Analyses of Test Samples
  申请人：SomaLogic, Inc.

  公开号：US20140249043A1

  公开（公告）日：2014-09-04

  The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.