9H-fluoren-9-ylmethyl 2,2,4,4-tetramethylpyrrolidine-1-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-fluoren-9-ylmethyl 2,2,4,4-tetramethylpyrrolidine-1-carboxylate
• 化学式: C₂₃H₂₇NO₂
• 分子量: 349.5
• InChiKey: CDQWILAKWHGWDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER<br/>[FR] SYNTHÈSE D'AMINES ACYCLIQUES ET CYCLIQUES AU MOYEN D'UN TRANSFERT DE GROUPE NITRÈNE CATALYSÉ PAR LE FER
  申请人：HARVARD COLLEGE

  公开号：WO2014134141A1

  公开（公告）日：2014-09-04

  The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C-H groups, catalyzed by a FeII-dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7- membered cyclic secondary amines) by reacting an azide that bears one or more C-H groups, catalyzed by a FeII-dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.

  本发明提供了一种制备无环二级胺的新型合成方法，通过将叠氮化物与含有一个或多个C-H基团的化合物反应，由FeII-二吡咯甲烷复合物催化。据认为，无环二级胺是通过分子间亚硝基转移形成的。本文还提供了一种合成受保护的（例如Boc-或Fmoc保护的）环状二级胺（例如5、6和7-环状二级胺）的方法，通过将带有一个或多个C-H基团的叠氮化物与FeII-二吡咯甲烷复合物催化反应。受保护的环状二级胺据认为是通过分子内亚硝基转移形成的，并且可以随后去保护以得到环状二级胺。
• SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20160002145A1

  公开（公告）日：2016-01-07

  The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.
• US9487472B2
  申请人：——

  公开号：US9487472B2

  公开（公告）日：2016-11-08
• US9724682B2
  申请人：——

  公开号：US9724682B2

  公开（公告）日：2017-08-08