N-methyl-1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione | 1037294-93-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-methyl-1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione
• 英文别名: 2-methyl-3,4-dihydro-1H-benzo[g]isoquinoline-5,10-dione
• CAS: 1037294-93-1
• 化学式: C₁₄H₁₃NO₂
• 分子量: 227.263
• InChiKey: WWRDFFAJUXUKOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-methyl-5,10-dimethoxy-1,2,3,4-tetrahydrobenz[g]isoquinoline 在 silver(II) oxide 、 硝酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 生成 N-methyl-1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione
  参考文献：
  名称：

  Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones

  摘要：

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.03.014

文献信息

• Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones
  作者：Jan Jacobs、Jurgen Deblander、Bart Kesteleyn、Kourosch Abbaspour Tehrani、Norbert De Kimpe

  DOI：10.1016/j.tet.2008.03.014

  日期：2008.5

  The synthesis of 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-dione hydrochlorides is reported starting from 1,4-dihydrobenz[g]isoquinoline-3(2H)-ones or ethyl (3-aminomethyl-1,4-dimethoxynaphth-2-yl)acetates. A third strategy relies on the synthesis of the title compounds via an N-protected 2-(3-bromomethyl-1,4-dimethoxynaphth-2-yl)ethylamine. The synthesized 1,2,3,4-tetrahydro-benz[g]isoquinoline-5,10-diones are a new class of quinones, which have not been reported yet. (C) 2008 Published by Elsevier Ltd.