[(1S,2R,3S,5S,6S,16E,18E,20R)-11-chloro-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[[4-(3-aminooxypropyldisulfanyl)-4-methylpentanoyl]-methylamino]propanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: [(1S,2R,3S,5S,6S,16E,18E,20R)-11-chloro-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[[4-(3-aminooxypropyldisulfanyl)-4-methylpentanoyl]-methylamino]propanoate
• 化学式: C₄₁H₆₁ClN₄O₁₀S₂
• 分子量: 869.5
• InChiKey: SXHFBTUITJXEHP-ASEPEURFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  58
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  222
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• [EN] CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS<br/>[FR] CONJUGUÉS COMPRENANT DES AGENTS DE LIAISON CELLULAIRE (CBA) ET DES AGENTS CYTOTOXIQUES
  申请人：IMMUNOGEN INC

  公开号：WO2014134483A2

  公开（公告）日：2014-09-04

  The invention provides linker compounds and cytotoxic compounds that are useful for forming a CBA-drug conjugates, and conjugates so formed. Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose.