7-[(4-Chlorophenyl)methyl]-1-(4-hydroxybutyl)-3-methyl-8-[3-(trifluoromethoxy)phenoxy]purine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-[(4-Chlorophenyl)methyl]-1-(4-hydroxybutyl)-3-methyl-8-[3-(trifluoromethoxy)phenoxy]purine-2,6-dione
• 英文别名: 7-[(4-chlorophenyl)methyl]-1-(4-hydroxybutyl)-3-methyl-8-[3-(trifluoromethoxy)phenoxy]purine-2,6-dione
• 化学式: C₂₄H₂₂ClF₃N₄O₅
• 分子量: 538.9
• InChiKey: VXKYLUJHRPDBOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  97.1
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF
  申请人：Hydra Biosciences, Inc.

  公开号：US20160237089A1

  公开（公告）日：2016-08-18

  Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

  本文描述了用于抑制TRPC5离子通道及与TRPC5相关的疾病的化合物、组合物和方法。
• Substituted xanthines and methods of use thereof
  申请人：Hydra Biosciences, Inc.

  公开号：US10399982B2

  公开（公告）日：2019-09-03

  Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

  描述了用于抑制 TRPC5 离子通道和与 TRPC5 相关疾病的化合物、组合物和方法。
• US20140275071A1
  申请人：——

  公开号：US20140275071A1

  公开（公告）日：2014-09-18
• Substituted Xanthines and Methods of Use Thereof
  申请人：Hydra Biosciences, Inc.

  公开号：US20170305910A1

  公开（公告）日：2017-10-26

  Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
• TRPC ION CHANNEL INHIBITORS FOR USE IN THERAPY
  申请人：UNIVERSITY OF LEEDS

  公开号：US20200345741A1

  公开（公告）日：2020-11-05

  Described herein are inhibitors Transient Receptor Potential Canonical (TRPC) ion channels comprising TRPC4 protein and/or TRPC5 protein for use in combating obesity and other medical conditions including insulin resistance associated with Type II diabetes or development of Type II diabetes (pre-diabetes), metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Also disclosed is the use of the inhibitors for cosmetic purposes, such as cosmetic weight loss.