H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH.TFA.H2O

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH.TFA.H2O
• 英文别名: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[2-[[2-[[2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2R)-2-amino-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoic acid;2,2,2-trifluoroacetic acid;hydrate
• 化学式: C100H141F3N24O36
• 分子量: 2312.3
• InChiKey: ODCZNMGPBWFNPG-HKRGSHRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.31
• 重原子数：
  163
• 可旋转键数：
  67
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  940
• 氢给体数：
  30
• 氢受体数：
  41

文献信息

• Systems and methods for delivery of peptides
  申请人：Transdermal Biotechnology, Inc.

  公开号：US10080768B2

  公开（公告）日：2018-09-25

  The present invention generally relates to compositions and methods for topical or transdermal delivery. The compositions can be used in a variety of applications. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. The composition can also be applied to a mucosal surface in some instances. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

  本发明一般涉及局部或透皮给药的组合物和方法。这些组合物可用于多种用途。在某些情况下，组合物可包括一氧化氮和/或肽。一氧化氮和/或肽可存在于包含卵磷脂（如磷脂酰胆碱）的第一阶段中。在某些实施方案中，卵磷脂存在于含有一氧化氮、肽或两者的脂质体、胶束或其他囊泡中。组合物可以是凝胶、膏霜、乳液、软膏、溶液、固体 "棒 "等形式，可以涂抹或喷洒在皮肤上。在某些情况下，组合物还可以涂抹在粘膜表面。本发明的其他方面一般涉及制造或使用这种组合物的方法、推广这种组合物的方法、包括这种组合物的成套工具或类似物。
• COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS
  申请人：The Regents of The University of Michigan

  公开号：EP3471778A2

  公开（公告）日：2019-04-24
• COMPOSITIONS AND METHODS FOR METAL CONTAINING FORMULATIONS CAPABLE OF MODULATING IMMUNE RESPONSE
  申请人：The Regents Of The University Of Michigan

  公开号：EP3820534A1

  公开（公告）日：2021-05-19
• US20140271731A1
  申请人：——

  公开号：US20140271731A1

  公开（公告）日：2014-09-18
• US20140271801A1
  申请人：——

  公开号：US20140271801A1

  公开（公告）日：2014-09-18