(3S,4R)-3-(2-propan-2-ylpyrazol-3-yl)oxane-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (3S,4R)-3-(2-propan-2-ylpyrazol-3-yl)oxane-4-carboxylic acid
• 化学式: C₁₂H₁₈N₂O₃
• 分子量: 238.28
• InChiKey: NAHXRKDHTODMIN-ZJUUUORDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] 1:1 ADDUCTS OF SICKLE HEMOGLOBIN<br/>[FR] PRODUITS D'ADDITION 1:1 D'HÉMOGLOBINE S
  申请人：GLOBAL BLOOD THERAPEUTICS INC

  公开号：WO2015116061A1

  公开（公告）日：2015-08-06

  Provide herein are 1:1 adducts of sickle hemoglobin (HbS) and a compound of formula (I), as defined herein, suitable as modulators of HbS, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

  本文提供了镰刀血红蛋白（HbS）与本文定义的化合物（I）的1:1加合物，适用作为HbS的调节剂，并提供了在治疗由血红蛋白介导的疾病以及需要组织和/或细胞氧合的疾病中使用它们的方法。
• BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
  申请人：Global Blood Therapeutics, Inc.

  公开号：US20150259296A1

  公开（公告）日：2015-09-17

  Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

  本文提供了适用作为血红蛋白调节剂的化合物和药物组合物，它们的制备方法和中间体，以及在治疗由血红蛋白介导的疾病和需要组织和/或细胞氧合的疾病中使用它们的方法。
• COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
  申请人：GLOBAL BLOOD THERAPEUTICS, INC.

  公开号：US20160031865A1

  公开（公告）日：2016-02-04

  Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

  本文提供了适用于血红蛋白调节剂的化合物和药物组合物，以及它们的制备方法和中间体，以及用于治疗由血红蛋白介导的疾病和需要组织和/或细胞氧合的疾病的方法。
• Compounds and uses thereof for the modulation of hemoglobin
  申请人：Global Blood Therapeutics, Inc.

  公开号：US10100040B2

  公开（公告）日：2018-10-16

  Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

  本文提供了适合作为血红蛋白调节剂的化合物和药物组合物、制备它们的方法和中间体，以及将它们用于治疗由血红蛋白介导的疾病和可从组织和/或细胞氧合中获益的疾病的方法。
• US20140275176A1
  申请人：——

  公开号：US20140275176A1

  公开（公告）日：2014-09-18