2-bromomethyl-7-methoxy-2,3-dihydro-1,4-benzodioxin | 304903-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 2-bromomethyl-7-methoxy-2,3-dihydro-1,4-benzodioxin
• 英文别名: 3-(Bromomethyl)-6-methoxy-2,3-dihydro-1,4-benzodioxine
• CAS: 304903-95-5
• 化学式: C₁₀H₁₁BrO₃
• 分子量: 259.1
• InChiKey: SEOOLJFMLFULJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-bromomethyl-7-methoxy-2,3-dihydro-1,4-benzodioxin 、 N-methyl-N-[2-[bis(p-fluorophenyl)methoxy]ethyl]amine 在 potassium carbonate 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 120.0h， 以50%的产率得到2-[bis(4-fluorophenyl)methoxy]-N-[(6-methoxy-2,3-dihydro-1,4-benzodioxin-3-yl)methyl]-N-methylethanamine
  参考文献：
  名称：

  Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists

  摘要：

  New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists. (C) 2000 editions scientifiques et medicates Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00164-1
• 作为产物：
  描述：

  2-hydroxymethyl-7-methoxy-2,3-dihydro-1,4-benzodioxin 在 N-溴代丁二酰亚胺(NBS) 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以70%的产率得到2-bromomethyl-7-methoxy-2,3-dihydro-1,4-benzodioxin
  参考文献：
  名称：

  Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists

  摘要：

  New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists. (C) 2000 editions scientifiques et medicates Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00164-1

文献信息

• Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists
  作者：Isabel Sánchez、Maria Dolors Pujol、Gerald Guillaumet、Roy Massingham、André Monteil、Georges Dureng、Eileen Winslow

  DOI：10.1016/s0223-5234(00)00164-1

  日期：2000.8

  New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists. (C) 2000 editions scientifiques et medicates Elsevier SAS.