[(2R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl 2-aminoacetate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: [(2R,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl 2-aminoacetate
• 化学式: C₁₂H₁₇N₃O₆
• 分子量: 299.28
• InChiKey: SDYAAWWBUREMQR-CFCGPWAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Methods and compositions for generating stable transfected cells
  申请人：MaxCyte, Inc.

  公开号：US10316335B2

  公开（公告）日：2019-06-11

  Methods and compositions are provided involving high producing cell lines. Embodiments concern efficient methods for screening for such cell lines and for creating such cell lines. These cell lines can be used to create large amounts of protein. To quickly generate large quantity of recombinant proteins or vaccines for both pre-clinical study and clinical trials, almost all drug development will face the same challenging obstacle of rapidly generating a high stable producer. Developing and identifying a stable cell line is a critical part of biopharmaceutical development.

  提供了涉及高产细胞系的方法和组合物。本发明涉及筛选此类细胞系和创建此类细胞系的有效方法。这些细胞系可用于制造大量蛋白质。为了快速产生大量重组蛋白或疫苗用于临床前研究和临床试验，几乎所有的药物开发都将面临同样的挑战，即快速产生高稳定性的生产者。开发和鉴定稳定的细胞系是生物制药开发的关键部分。
• METHODS AND COMPOSITIONS FOR GENERATING STABLE TRANSFECTED CELLS
  申请人：Maxcyte, Inc.

  公开号：EP2970915B1

  公开（公告）日：2019-08-14
• Methods and Compositions for Generating Stable Transfected Cells
  申请人：MAXCYTE, INC.

  公开号：US20160053283A1

  公开（公告）日：2016-02-25

  Methods and compositions are provided involving high producing cell lines. Embodiments concern efficient methods for screening for such cell lines and for creating such cell lines. These cell lines can be used to create large amounts of protein. To quickly generate large quantity of recombinant proteins or vaccines for both pre-clinical study and clinical trials, almost all drug development will face the same challenging obstacle of rapidly generating a high stable producer. Developing and identifying a stable cell line is a critical part of biopharmaceutical development.
• [EN] METHODS AND COMPOSITIONS FOR GENERATING STABLE TRANSFECTED CELLS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA GÉNÉRATION DE CELLULES TRANSFECTÉES DE FAÇON STABLE
  申请人：MAXCYTE INC

  公开号：WO2014144237A1

  公开（公告）日：2014-09-18

  Methods and compositions are provided involving high producing cell lines. Embodiments concern efficient methods for screening for such cell lines and for creating such cell lines. These cell lines can be used to create large amounts of protein. To quickly generate large quantity of recombinant proteins or vaccines for both pre-clinical study and clinical trials, almost all drug development will face the same challenging obstacle of rapidly generating a high stable producer. Developing and identifying a stable cell line is a critical part of biopharmaceutical development.