2-Amino-3-(cyclobutadienyl)imidazo[4,5-b]pyridine-5-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-Amino-3-(cyclobutadienyl)imidazo[4,5-b]pyridine-5-carbonitrile
• 英文别名: 2-amino-3-(cyclobutadienyl)imidazo[4,5-b]pyridine-5-carbonitrile
• 化学式: C₁₁H₇N₅
• 分子量: 209.21
• InChiKey: WOHMWQBZEYBAHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS
  申请人：Knopp Biosciences LLC

  公开号：US20160075663A1

  公开（公告）日：2016-03-17

  Optionally substituted benzoimidazol-1,2-yl amides, such as compounds of Formula 1 or Formula 2, can be used to treat disorders associated with a Kv7 potassium channel activator. Compositions, medicaments, and dosage forms related to the treatment are also disclosed herein.

  可选择替代的苯并咪唑-1,2-基酰胺，如式1或式2的化合物，可用于治疗与Kv7钾通道激活剂相关的疾病。本文还公开了与治疗相关的组合物、药物和剂型。
• IMIDAZO(4,5-B) PYRIDIN-2-YL AMIDES AS KV7 CHANNEL ACTIVATORS
  申请人：KNOPP BIOSCIENCES LLC

  公开号：US20160031875A1

  公开（公告）日：2016-02-04

  Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related to seizures, pain, neurotransmitter release, etc.

  由公式1表示的化合物可能对Kv7.2/7.3异源多聚体具有强效和/或部分选择性。它们可能在治疗与癫痫、疼痛、神经递质释放等相关的疾病方面有用。
• BENZOIMIDAZOL-1,2-YL AMIDES AS KV7 CHANNEL ACTIVATORS
  申请人：Knopp Biosciences LLC

  公开号：EP3572405A1

  公开（公告）日：2019-11-27

  Optionally substituted benzoimidazol-1,2-yl amides (formula) can be used to treat disorders associated with a Kv7 potassium channel activator. Compositions, medicaments, and dosage forms related to the treatment are also disclosed herein.

  任选取代的苯并咪唑-1,2-基酰胺（式）可用于治疗与 Kv7 钾通道激活剂相关的疾病。本文还公开了与治疗相关的组合物、药物和剂型。
• Imidazo(4,5-B) pyridin-2-yl amides as KV7 channel activators
  申请人：Knopp Biosciences LLC

  公开号：US10106536B2

  公开（公告）日：2018-10-23

  Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related to seizures, pain, neurotransmitter release, etc.

  式 1 所代表的化合物对 Kv7.2/7.3 异源二聚体具有强效和/或部分选择性。它们可用于治疗与癫痫发作、疼痛、神经递质释放等有关的疾病。
• Benzoimidazol-1,2-yl amides as Kv7 channel activators
  申请人：Knopp Biosciences LLC

  公开号：US10385025B2

  公开（公告）日：2019-08-20

  Optionally substituted benzoimidazol-1,2-yl amides, such as compounds of Formula 1 or Formula 2, can be used to treat disorders associated with a Kv7 potassium channel activator. Compositions, medicaments, and dosage forms related to the treatment are also disclosed herein.

  任选取代的苯并咪唑-1,2-基酰胺，如式 1 或式 2 的化合物，可用于治疗与 Kv7 钾通道激活剂相关的疾病。本文还公开了与治疗相关的组合物、药物和剂型。