2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one;N-methyltetradecan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one;N-methyltetradecan-1-amine
• 化学式: C23H44N6O3
• 分子量: 452.6
• InChiKey: IOSJJOBCCVCGCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.58
• 重原子数：
  32
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] NUCLEOSIDE ANALOG SALTS WITH IMPROVED SOLUBILITY AND METHODS OF FORMING SAME<br/>[FR] SELS D'ANALOGUES DE NUCLÉOSIDES AYANT UNE SOLUBILITÉ AMÉLIORÉE ET LEURS PROCÉDÉS DE FORMATION
  申请人：UNIV ALABAMA

  公开号：WO2014145464A1

  公开（公告）日：2014-09-18

  Disclosed are salts of nucleoside analogs and methods of forming the salts. An anion of a nucleoside analog is paired with a permanent counter cation to form a salt that has decreased melting point and increased aqueous solubility compared to the nucleoside compound prior to the salt formation. Also a cation of a nucleoside analog is paired with a permanent counter anion to form a salt that has decreased melting point and increased aqueous solubility compared to the nucleoside compound prior to the salt formation. The nucleoside analog in some embodiments has therapeutic activity such as antiviral. The permanent counter cation or anion in some embodiments has bioactivity such as antibacterial or being a vitamin.

  揭示了核苷类似物的盐及形成这些盐的方法。核苷类似物的阴离子与永久性对离子结合形成盐，与盐形成之前的核苷类似物相比，该盐具有较低的熔点和较高的水溶性。此外，核苷类似物的阳离子与永久性对离子结合形成盐，与盐形成之前的核苷类似物相比，该盐具有较低的熔点和较高的水溶性。在某些实施例中，核苷类似物具有抗病毒等治疗活性。在某些实施例中，永久性对离子具有生物活性，如抗菌活性或维生素活性。
• NUCLEOSIDE ANALOG SALTS WITH IMPROVED SOLUBILITY AND METHODS OF FORMING SAME
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA

  公开号：US20160002240A1

  公开（公告）日：2016-01-07

  Disclosed are salts of nucleoside analogs and methods of forming the salts. An anion of a nucleoside analog is paired with a permanent counter cation to form a salt that has decreased melting point and increased aqueous solubility compared to the nucleoside compound prior to the salt formation. Also a cation of a nucleoside analog is paired with a permanent counter anion to form a salt that has decreased melting point and increased aqueous solubility compared to the nucleoside compound prior to the salt formation. The nucleoside analog in some embodiments has therapeutic activity such as antiviral. The permanent counter cation or anion in some embodiments has bioactivity such as antibacterial or being a vitamin.

  本发明涉及核苷类似物的盐及其制备方法。将核苷类似物的负离子与永久性对离子结合形成盐，使得盐的熔点降低，水溶性增加，与盐形成前的核苷化合物相比更优。此外，将核苷类似物的正离子与永久性对阴离子结合形成盐，使得盐的熔点降低，水溶性增加，与盐形成前的核苷化合物相比更优。在某些实施方式中，核苷类似物具有抗病毒等治疗活性。在某些实施方式中，永久性对离子具有抗菌或维生素等生物活性。