5-Octadiynyl deoxyuridine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-Octadiynyl deoxyuridine
• 英文别名: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-octa-1,3-diynylpyrimidine-2,4-dione
• 化学式: C₁₇H₂₀N₂O₅
• 分子量: 332.4
• InChiKey: FDVNEWMFROVJBD-RRFJBIMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• SPECIFIC MULTIVALENT VIRUS-LIKE PARTICLE VACCINES AND USES THEREOF
  申请人：Bullet Biotechnology, Inc.

  公开号：EP2968517A2

  公开（公告）日：2016-01-20
• SPECIFIC VIRUS-LIKE PARTICLE-CPG OLIGONUCLEOTIDE VACCINES AND USES THEREOF
  申请人：Bullet Biotechnology, Inc.

  公开号：EP3079717A1

  公开（公告）日：2016-10-19
• SPECIFIC VIRUS-LIKE PARTICLE-CpG OLIGONUCLEOTIDE VACCINES AND USES THEREOF
  申请人：Bullet Biotechnology, Inc.

  公开号：US20170035864A1

  公开（公告）日：2017-02-09

  The invention provides vaccines containing, as its only active ingredient, a VLP having a CpG oligonucleotide attached thereto and a non-toxic pharmaceutically acceptable carrier or diluent and uses thereof. The invention further provides a pharmaceutical composition comprising a vaccine consisting of a VLP having a CpG oligonucleotide, one or more non-toxic pharmaceutically acceptable carrier or diluent, and a therapeutic agent admixture therewith and uses thereof.
• [EN] SPECIFIC MULTIVALENT VIRUS-LIKE PARTICLE VACCINES AND USES THEREOF<br/>[FR] VACCINS À PARTICULES DE TYPE VIRAL MULTIVALENTS SPÉCIFIQUES ET LEURS UTILISATIONS
  申请人：BULLET BIOTECHNOLOGY INC

  公开号：WO2014145932A2

  公开（公告）日：2014-09-18

  The invention provides a VLP free of a viral genome comprising two or more display polypeptides, nucleic acid molecules, polymers of the nucleic acid, lipopolysaccharides, lipopeptides, peptidoglycans and/or small molecules.
• [EN] SPECIFIC VIRUS-LIKE PARTICLE-CPG OLIGONUCLEOTIDE VACCINES AND USES THEREOF<br/>[FR] VACCINS CONTENANT UNE PARTICULE PSEUDO-VIRALE COMPORTANT UN OLIGONUCLÉOTIDE SPÉCIFIQUE CPG ET LERUS UTILISATIONS
  申请人：BULLET BIOTECHNOLOGY INC

  公开号：WO2015089114A1

  公开（公告）日：2015-06-18

  The invention provides vaccines containing, as its only active ingredient, a VLP having a CpG oligonucleotide attached thereto and a non-toxic pharmaceutically acceptable carrier or diluent and uses thereof. The invention further provides a pharmaceutical composition comprising a vaccine consisting of a VLP having a CpG oligonucleotide, one or more non-toxic pharmaceutically acceptable carrier or diluent, and a therapeutic agent admixture therewith and uses thereof.