2-[9H-fluoren-9-ylmethoxycarbonyl-[2-[(2-methylpropan-2-yl)oxy]-2-(3,7,7-trimethyl-2-bicyclo[4.1.0]hept-1-enyl)ethyl]amino]acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-[9H-fluoren-9-ylmethoxycarbonyl-[2-[(2-methylpropan-2-yl)oxy]-2-(3,7,7-trimethyl-2-bicyclo[4.1.0]hept-1-enyl)ethyl]amino]acetic acid
• 化学式: C₃₃H₄₁NO₅
• 分子量: 531.7
• InChiKey: BRLBJYBSGVNPGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE
  申请人：Capon, Daniel J.

  公开号：EP2968495A2

  公开（公告）日：2016-01-20
• [EN] HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE<br/>[FR] IMMUNOGLOBULINE HYBRIDE CONTENANT UNE LIAISON NON PEPTIDIQUE
  申请人：CAPON DANIEL J

  公开号：WO2014144911A2

  公开（公告）日：2014-09-18

  The present invention provides compounds producing compounds having the structure (I). Wherein A is a first polypeptide component of the compound; wherein C is a second polypeptide component of the compound, which polypeptide component comprises consecutive amino acids which (i) are identical to a stretch of consecutive amino acids present in a chain of an Fc domain of an antibody; (ii) bind to an Fc receptor; and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine, selenocysteine, CP, CPXCP (where X = P, R, or S), CDKTHTCPPCP, CVECPPCP, CCVECPPCP and CDTPPPCPRCP, wherein B is a chemical structure linking A and C; wherein the dashed line between B and C represents a peptidyl linkage; wherein the solid line between A and B represents a nonpeptidyl linkage comprising the structure (II).