6-piperidin-1-ylmethylbenzo[4,5]imidazo[1,2-c]quinazoline | 70371-95-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-piperidin-1-ylmethylbenzo[4,5]imidazo[1,2-c]quinazoline
• 英文别名: 6-Piperidin-1-ylmethyl-benzo[4,5]imidazo[1,2-c]quinazoline；6-(piperidin-1-ylmethyl)benzimidazolo[1,2-c]quinazoline
• CAS: 70371-95-8
• 化学式: C₂₀H₂₀N₄
• 分子量: 316.406
• InChiKey: HWMHNDMGBOYMBQ-UHFFFAOYSA-N

物化性质

• 熔点：
  145-146 °C(Solv: heptane (142-82-5))
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  33.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-piperidin-1-ylmethylbenzo[4,5]imidazo[1,2-c]quinazoline 在 盐酸 、 水 作用下， 反应 0.08h， 生成 N-[2-(1H-benzoimidazol-2-yl)phenyl]-2-piperidin-1-ylacetamide hydrochloride
  参考文献：
  名称：

  Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines

  摘要：

  Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzojmidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K-a values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.03.004
• 作为产物：
  描述：

  哌啶 、 6-chloromethylbenzo[4,5]imidazo[1,2-c]quinazoline 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以61%的产率得到6-piperidin-1-ylmethylbenzo[4,5]imidazo[1,2-c]quinazoline
  参考文献：
  名称：

  Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines

  摘要：

  Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzojmidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K-a values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.03.004

文献信息

• BOGATSKIJ A. V.; IVANOV EH. I.; BOCTPOBA L. N.; GRENADEROVA M. V.; KARAVA+, UKR. XIM. ZH., 1979, 45, HO 3, 225-230
  作者：BOGATSKIJ A. V.、 IVANOV EH. I.、 BOCTPOBA L. N.、 GRENADEROVA M. V.、 KARAVA+

  DOI：——

  日期：——
• Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
  作者：Elena A. Lyakhova、Yulia A. Gusyeva、Julia V. Nekhoroshkova、Lev M. Shafran、Sergey A. Lyakhov

  DOI：10.1016/j.ejmech.2009.03.004

  日期：2009.8

  Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzojmidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K-a values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives. (C) 2009 Elsevier Masson SAS. All rights reserved.