[(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-4,4,8,8-tetramethyltridec-6-enoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: [(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-4,4,8,8-tetramethyltridec-6-enoate
• 化学式: C₂₀H₃₉O₇P
• 分子量: 422.5
• InChiKey: AHDKCFXDKQEQEU-QJWNTBNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] ENRICHMENT OF LYSOPHOSPHATIDIC ACIDS WITH TEMPLATED POLYMERIC MATERIALS<br/>[FR] ENRICHISSEMENT D'ACIDES LYSOPHOSPHATIDIQUES PAR DES MATÉRIAUX POLYMÈRES À MATRICE
  申请人：UNIV PORTLAND STATE

  公开号：WO2016137953A1

  公开（公告）日：2016-09-01

  Embodiments of templated polymeric materials capable of binding lysophosphatidic acids (LPAs) are disclosed. Methods of making and using the templated polymeric materials also are disclosed. The disclosed templated polymeric materials are molecularly imprinted polymers that bind LPAs and facilitate the production of lysophosphatidic acid-enriched samples, for instance through extraction of lysophosphatidic acids from biological samples, such as plasma or serum samples.

  本文披露了能够结合溶血磷脂酸（LPAs）的模板聚合物材料的实施方式。还披露了制备和使用模板聚合物材料的方法。所披露的模板聚合物材料是分子印迹聚合物，能够结合LPAs并促进溶血磷脂酸富集样品的生产，例如通过从生物样品（如血浆或血清样品）中提取溶血磷脂酸。
• [EN] LYSOPHOSPHATIDIC ACID DETECTION<br/>[FR] DÉTECTION D'ACIDE LYSOPHOSPHATIDIQUE
  申请人：OREGON STATE

  公开号：WO2014144561A2

  公开（公告）日：2014-09-18

  Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.