tetrakis(ammoniomethyl)methane disulfate | 69898-47-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: tetrakis(ammoniomethyl)methane disulfate
• 英文别名: 2,2-bis-aminomethyl-propanediyldiamine; disulfate；2,2-Bis-aminomethyl-propandiyldiamin; Disulfat；2,2-Bis(aminomethyl)propane-1,3-diamine;sulfuric acid
• CAS: 69898-47-1
• 化学式: C₅H₂₀N₄*2O₄S
• 分子量: 328.368
• InChiKey: XVBWVGRWQZJSHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.85
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  187
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,1-diiodo-2,2-dinitroethylene 、 tetrakis(ammoniomethyl)methane disulfate 在 三乙胺 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 以92%的产率得到3,9-Bis(dinitromethylene)-2,4,8,10-tetraazaspiro<5.5>undecane
  参考文献：
  名称：

  Synthesis and reactions of 1,1-diiododinitroethylene

  摘要：

  The nitration of tetraiodoethylene gave 1,1-diiododinitroethylene (1). X-ray crystallography showed that one of the two nitro groups is perpendicular to the ethylene plane. Simple amines (dimethylamine, propylamine, aniline) reacted with 1 to give 1,1-diamino-2,2-dinitroethylene derivatives; diamines (o-phenylenediamine, ethylenediamine, 1,3-diaminopropane, 1,4-diaminobutane) gave the corresponding cyclic products, and a tetramine [(tetrakis(aminomethyl)methane] gave the analogous spiro derivative. Ammonia gave only ammonium cyanodinitromethide, whereas phenol gave 1,1-dinitro-2,2,2-triphenoxyethane. The reaction of 1 with potassium nitrite gave the dipotassium salt of tetranitroethane. X-ray crystallography of the 1,1-diamino-2,2-dinitroethylenes showed twisted olefins, some with twist angles greater than any previously reported for twisted ethylenes, with concomitant bond-distance distortions.

  DOI：

  10.1021/jo00027a042

文献信息

• Multiligand constructs
  申请人：SEMIOTIK LLC

  公开号：US09221879B2

  公开（公告）日：2015-12-29

  Multiligand constructs and intermediate multivalent constructs for use in their preparation are described. The multiligand constructs have utility in diagnostic and therapeutic applications.

  描述了用于制备多配体构建物和中间多价构建物的多配体构建物。这些多配体构建物在诊断和治疗应用中具有实用性。
• McAuley, A.; Subramanian, S.; Whitcombe, T. W., Canadian Journal of Chemistry, 1989, vol. 67, p. 1650 - 1656
  作者：McAuley, A.、Subramanian, S.、Whitcombe, T. W.

  DOI：——

  日期：——
• Synthesis and reactions of 1,1-diiododinitroethylene
  作者：Kurt Baum、Sean S. Bigelow、Nguyen Nghi Van、Thomas G. Archibald、Richard Gilardi、Judith L. Flippen-Anderson、Clifford George

  DOI：10.1021/jo00027a042

  日期：1992.1

  The nitration of tetraiodoethylene gave 1,1-diiododinitroethylene (1). X-ray crystallography showed that one of the two nitro groups is perpendicular to the ethylene plane. Simple amines (dimethylamine, propylamine, aniline) reacted with 1 to give 1,1-diamino-2,2-dinitroethylene derivatives; diamines (o-phenylenediamine, ethylenediamine, 1,3-diaminopropane, 1,4-diaminobutane) gave the corresponding cyclic products, and a tetramine [(tetrakis(aminomethyl)methane] gave the analogous spiro derivative. Ammonia gave only ammonium cyanodinitromethide, whereas phenol gave 1,1-dinitro-2,2,2-triphenoxyethane. The reaction of 1 with potassium nitrite gave the dipotassium salt of tetranitroethane. X-ray crystallography of the 1,1-diamino-2,2-dinitroethylenes showed twisted olefins, some with twist angles greater than any previously reported for twisted ethylenes, with concomitant bond-distance distortions.