2-Hydroxy-2-(2-hydroxy-phenyl)-propionic acid | 89666-09-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-Hydroxy-2-(2-hydroxy-phenyl)-propionic acid
• 英文别名: 2-Hydroxy-2-(2-hydroxyphenyl)propanoic acid
• CAS: 89666-09-1
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: LZMHQYDDHVJXQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙酮酸 、 苯酚 在 四氯化钛 作用下， 生成 2-Hydroxy-2-(2-hydroxy-phenyl)-propionic acid
  参考文献：
  名称：

  A Facile and Efficient Synthesis of (o-Hydroxyaryl)-glycolic Acid Derivatives

  摘要：

  DOI：

  10.1055/s-1984-30961

文献信息

• Process for producing a-hydroxy acid ammonium salt
  申请人：Kobayashi Yoichi

  公开号：US20050176116A1

  公开（公告）日：2005-08-11

  The present invention provides a method for producing. a-hydroxy acid ammonium salt that uses a specific microbial strain capable of accumulating α-hydroxy acid ammonium salt at a high concentration while also maintaining an industrially satisfactory production rate for a long period of time. More specifically, the present invention uses a microbial catalyst originating in a microbial strain which, during conversion of α-hydroxynitrile to α-hydroxy acid ammonium salt, is capable of maintaining the average production rate of α-hydroxy acid ammonium salt at at least 100 μmol/min per g of dry microbial cell weight for 14 days or more without adding fresh microbial catalyst, and is capable of accumulating the α-hydroxy acid ammonium salt at 20 to 60% by weight. An example of this microbial strain is Arthrobacter sp. strain NSSC204.

  本发明提供了一种生产α-羟基酸铵盐的方法，该方法使用一种特定的微生物菌株，该菌株能够在长时间内保持工业上满意的生产速率，同时能够以高浓度积累α-羟基酸铵盐。更具体地说，本发明使用一种微生物催化剂，该催化剂源自一种微生物菌株，该菌株在将α-羟基腈转化为α-羟基酸铵盐过程中，能够在不添加新的微生物催化剂的情况下，将α-羟基酸铵盐的平均生产速率保持在每克干微生物细胞重至少100μmol/min以上，且能够将α-羟基酸铵盐积累到20%至60%的重量。这种微生物菌株的一个例子是Arthrobactersp.菌株NSSC204。
• Phenylpyruvate Reductase and Method for Manufacturing Optically-Active Phenyllactic Acid and 4-Hydroxyl-Phenyllactic Acid Using Same Enzyme
  申请人：Konishi Kazunobu

  公开号：US20140073024A1

  公开（公告）日：2014-03-13

  The present invention provides a phenylpyruvate reductase for efficiently obtaining highly pure, optically active 3-phenyllactate and 4-hydroxyphenyllactate; a gene coding for the same; and a method for manufacturing optically active 3-phenyllactate and 4-hydroxyphenyllactate employing the same.

  本发明提供了一种苯丙酸还原酶，可高效地获得高纯度、光学活性的3-苯乳酸和4-羟基苯乳酸；一种编码相同的基因；以及利用该基因制造光学活性3-苯乳酸和4-羟基苯乳酸的方法。
• Process for preparing (o-hydroxyaryl)-methanols
  申请人：BLASCHIM S.p.A.

  公开号：EP0098012A2

  公开（公告）日：1984-01-11

  A process for preparing (o-hydroxyaryl)-methanols by reacting a phenol-derivative with a compound of formula R(OCO)m COY (where R is hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, heterocyclic; m is 0 or 1; and Y is COR, CR(OB)2, COOR or CN, where R has the above mentioned meaning and B is alkyl, arylalkyl or both B radicals are an alkylidene radical which together with the group -0-C-O-to which it is bound, is forming an alicyclic system) in the presence of a Lewis acid. The compounds thus obtained are new excepting when m is 0, R is H, Y is COOH and the starting phenol derivative is 4-chloro-, 2-methoxy, 2-methyl, 2,4-dibromo-, 2,4-dimethyl-, 3,4-dimethyl- or 3,6-dimethyl-phenol. Preferred Lewis acids are the derivates of metals having a high valence degree.

  一种通过使苯酚衍生物与式 R(OCO)m COY（其中 R 是氢、烷基、取代烷基、环烷基、芳基、杂环基；m 是 0 或 1；Y 是 COR、CR(OB)2、COOR 或 CN，其中 R 具有上述含义，B 是烷基、芳烷基或两个 B 基都是亚烷基，它们与所结合的基团-0-C-O 一起形成脂环体系）。 除 m 为 0、R 为 H、Y 为 COOH 且起始苯酚衍生物为 4-氯-、2-甲氧基、2-甲基、2,4-二溴-、2,4-二甲基-、3,4-二甲基-或 3,6- 二甲基-苯酚外，由此获得的化合物都是新化合物。 首选的路易斯酸是高价金属的衍生物。
• Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use
  申请人：Yu, Ruey J., Dr.

  公开号：EP0413528A1

  公开（公告）日：1991-02-20

  Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclosed. The cosmetic conditions and the dermatologic disorders in which the amphoteric compositions and the polymeric compounds may be useful include dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, kyperkeratotic skin, inflammatory dermatoses, skin changes associated with aging, and skin requiring cleansers.

  本发明公开了含有α-羟基酸、α-酮酸、相关化合物或羟基酸聚合形式的两性组合物的预防和治疗方法，以缓解美容状况和皮肤病症状。两性组合物和聚合化合物可用于治疗的美容病症和皮肤病包括皮肤干燥、头皮屑、痤疮、角化病、牛皮癣、湿疹、瘙痒症、老年斑、色斑、黑斑、皱纹、疣、瑕疵皮肤、色素沉着皮肤、角化过度皮肤、炎症性皮肤病、与衰老有关的皮肤变化以及需要清洁剂的皮肤。
• PROCESS FOR PRODUCING A-HYDROXY ACID AMMONIUM SALT
  申请人：NIPPON SODA CO., LTD.

  公开号：EP1466984A1

  公开（公告）日：2004-10-13

  The present invention provides a method for producing a-hydroxy acid ammonium salt that uses a specific microbial strain capable of accumulating α-hydroxy acid ammonium salt at a high concentration while also maintaining an industrially satisfactory production rate for a long period of time. More specifically, the present invention uses a microbial catalyst originating in a microbial strain which, during conversion of α-hydroxynitrile to α-hydroxy acid ammonium salt, is capable of maintaining the average production rate of α-hydroxy acid ammonium salt at at least 100 µmol/min per g of dry microbial cell weight for 14 days or more without adding fresh microbial catalyst, and is capable of accumulating the α-hydroxy acid ammonium salt at 20 to 60% by weight. An example of this microbial strain is Arthrobacter sp. strain NSSC204.

  本发明提供了一种生产α-羟基酸铵盐的方法，该方法使用一种特定的微生物菌株，该菌株能够以高浓度积累α-羟基酸铵盐，同时还能长期保持工业上令人满意的生产率。更具体地说，本发明使用的微生物催化剂来源于一种微生物菌株，该微生物菌株在将α-羟腈转化为α-羟酸铵盐的过程中，能够在不添加新鲜微生物催化剂的情况下，将α-羟酸铵盐的平均生产率维持在每克干微生物细胞重量至少100微摩尔/分钟，持续14天或更长时间，并且能够将α-羟酸铵盐累积到20%至60%（按重量计）。这种微生物菌株的一个例子是节杆菌菌株 NSSC204。