9-[(6aR)-6-ethyl-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-4,5-dihydropurin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-[(6aR)-6-ethyl-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-4,5-dihydropurin-6-amine
• 化学式: C₁₄H₂₁N₅O₃
• 分子量: 307.35
• InChiKey: BVSTUPYPTPGBAA-RKMYTIFBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  94
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• US20140271945A1
  申请人：——

  公开号：US20140271945A1

  公开（公告）日：2014-09-18
• IMMUNOASSAY OF S-ADENOSYLMETHIONINE IN PERSONALIZED MEDICINE AND HEALTH OR CANCER EVALUATION
  申请人：Hao Xiujuan

  公开号：US20150268231A1

  公开（公告）日：2015-09-24

  The invention provides a method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes test strips which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.