5,6-dihydro-2,3-dimethoxy-5-oxo-7-aza-11H-indeno[1,2-c]isoquinoline | 1324006-68-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5,6-dihydro-2,3-dimethoxy-5-oxo-7-aza-11H-indeno[1,2-c]isoquinoline
• 英文别名: 7-aza-5,6-dihydro-2,3-dimethoxy-5-oxo-11H-indeno[1,2-c]isoquinoline；4,5-Dimethoxy-9,12-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,11(16),12,14-heptaen-8-one
• CAS: 1324006-68-9
• 化学式: C₁₇H₁₄N₂O₃
• 分子量: 294.31
• InChiKey: LNBGTOGPUFLQAH-UHFFFAOYSA-N

物化性质

• 熔点：
  284-286 °C
• 沸点：
  598.1±50.0 °C(predicted)
• 密度：
  1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5,6-dihydro-2,3-dimethoxy-5-oxo-7-aza-11H-indeno[1,2-c]isoquinoline 在 selenium(IV) oxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 以26%的产率得到5,6-dihydro-2,3-dimethoxy-5,11-dioxo-7-aza-11H-indeno[1,2-c]isoquinoline
  参考文献：
  名称：

  7-Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents

  摘要：

  A series of 7-azaindenoisoquinoline topoisomerase I (Top 1) inhibitors have been prepared to investigate the effect of increased electron affinity of the aromatic system on the ability to stabilize the Top1-DNA cleavage complex. Ab initio calculations suggest that introduction of nitrogen into the aromatic system of the indenoisoquinolines would facilitate charge transfer complex formation with DNA, thus improving the pi-pi stacking interactions. The present study shows that 7-azaindenoisoquinolines demonstrate improved water solubility without any decrease in Top1 inhibitory activity or cytotoxicity. Analysis of the biological results reveals that smaller lactam ring substituents enable intercalation into both free DNA and Top1-DNA cleavage complex, whereas larger substituents only allow binding to the cleavage complex but not free DNA. Free DNA binding suppresses Top1-catalyzed DNA cleavage at high drug concentrations, whereas DNA cleavage and inhibition of religation occurs at low drug concentration.

  DOI：

  10.1021/jm200719v
• 作为产物：
  描述：

  2-氰基-3-甲基吡啶 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 三乙胺 作用下， 以 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 12.0h， 生成 5,6-dihydro-2,3-dimethoxy-5-oxo-7-aza-11H-indeno[1,2-c]isoquinoline
  参考文献：
  名称：

  7-Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents

  摘要：

  A series of 7-azaindenoisoquinoline topoisomerase I (Top 1) inhibitors have been prepared to investigate the effect of increased electron affinity of the aromatic system on the ability to stabilize the Top1-DNA cleavage complex. Ab initio calculations suggest that introduction of nitrogen into the aromatic system of the indenoisoquinolines would facilitate charge transfer complex formation with DNA, thus improving the pi-pi stacking interactions. The present study shows that 7-azaindenoisoquinolines demonstrate improved water solubility without any decrease in Top1 inhibitory activity or cytotoxicity. Analysis of the biological results reveals that smaller lactam ring substituents enable intercalation into both free DNA and Top1-DNA cleavage complex, whereas larger substituents only allow binding to the cleavage complex but not free DNA. Free DNA binding suppresses Top1-catalyzed DNA cleavage at high drug concentrations, whereas DNA cleavage and inhibition of religation occurs at low drug concentration.

  DOI：

  10.1021/jm200719v

文献信息

• AZAINDENOISOQUINOLINE TOPOISOMERASE I INHIBITORS
  申请人：CUSHMAN Mark S.

  公开号：US20140018360A1

  公开（公告）日：2014-01-16

  The invention described herein pertains to substituted azaindenoisoquinoline compounds, in particular 7-, 8-, 9-, and 10-azaindenoisoquinoline compounds, which are inhibitors of topoisomerase I, processes and intermediates for their syntheses, pharmaceutical compositions of the compounds, and methods of using them in the treatment of cancer.

  本发明涉及替代的氮杂吲哚异异喹啉化合物，特别是7-、8-、9- 和10-氮杂吲哚异异喹啉化合物，它们是拓扑异构酶I的抑制剂，以及用于合成它们的过程和中间体，这些化合物的药物组合物，以及在癌症治疗中使用它们的方法。
• US9034870B2
  申请人：——

  公开号：US9034870B2

  公开（公告）日：2015-05-19
• 7-Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents
  作者：Evgeny Kiselev、Sean DeGuire、Andrew Morrell、Keli Agama、Thomas S. Dexheimer、Yves Pommier、Mark Cushman

  DOI：10.1021/jm200719v

  日期：2011.9.8

  A series of 7-azaindenoisoquinoline topoisomerase I (Top 1) inhibitors have been prepared to investigate the effect of increased electron affinity of the aromatic system on the ability to stabilize the Top1-DNA cleavage complex. Ab initio calculations suggest that introduction of nitrogen into the aromatic system of the indenoisoquinolines would facilitate charge transfer complex formation with DNA, thus improving the pi-pi stacking interactions. The present study shows that 7-azaindenoisoquinolines demonstrate improved water solubility without any decrease in Top1 inhibitory activity or cytotoxicity. Analysis of the biological results reveals that smaller lactam ring substituents enable intercalation into both free DNA and Top1-DNA cleavage complex, whereas larger substituents only allow binding to the cleavage complex but not free DNA. Free DNA binding suppresses Top1-catalyzed DNA cleavage at high drug concentrations, whereas DNA cleavage and inhibition of religation occurs at low drug concentration.