(1R,16E,18E,21S)-11-chloro-6,21-dihydroxy-12,20-dimethoxy-5,9,16-trimethyl-24-oxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaene-8,23-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: (1R,16E,18E,21S)-11-chloro-6,21-dihydroxy-12,20-dimethoxy-5,9,16-trimethyl-24-oxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaene-8,23-dione
• 化学式: C₂₈H₃₇ClN₂O₇
• 分子量: 549.1
• InChiKey: FFYGPKOWVNKKFU-ADCIGAOKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  38
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• US20140271676A1
  申请人：——

  公开号：US20140271676A1

  公开（公告）日：2014-09-18
• FC CONTAINING POLYPEPTIDES WITH ALTERED GLYCOSYLATION AND REDUCED EFFECTOR FUNCTION
  申请人：Genzyme Corporation

  公开号：US20170107276A9

  公开（公告）日：2017-04-20

  Provided are binding polypeptides (e.g., antibodies), and drug conjugates thereof, comprising an Fc domain with an altered glycosylation profile and reduced effector function. In particular embodiment, the Fc domain comprises: an asparagine residue at amino acid position 298, according to EU numbering; and a serine threonine residue at amino acid position 300, according to EU numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
• US9790268B2
  申请人：——

  公开号：US9790268B2

  公开（公告）日：2017-10-17