(3Z)-3-[(3-bromo-4-hydroxy-5-methoxyphenyl)methylidene]-1H-indol-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (3Z)-3-[(3-bromo-4-hydroxy-5-methoxyphenyl)methylidene]-1H-indol-2-one
• 化学式: C₁₆H₁₂BrNO₃
• 分子量: 346.17
• InChiKey: QKYWLUVNWAQTIR-WDZFZDKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHODS, COMPOSITIONS AND KITS FOR PROMOTING MOTOR NEURON SURVIVAL AND TREATING AND DIAGNOSING NEURODEGENERATIVE DISORDERS
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20160082015A1

  公开（公告）日：2016-03-24

  Methods, compositions, and kits for promoting motor neuron survival and for treatment and diagnosis of neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS) and Spinal muscular atrophy (SMA) are described herein.

  本文描述了促进运动神经元存活以及治疗和诊断神经退行性疾病，如肌萎缩侧索硬化症（ALS）和脊髓性肌萎缩症（SMA）的方法、组合物和试剂盒。
• Methods and compositions for the treatment of neurodegenerative disorders
  申请人：Jin Xiaowei

  公开号：US20080044390A1

  公开（公告）日：2008-02-21

  The present invention features compositions, kits, and methods for treating, preventing, and ameliorating neurodegenerative disorders, e.g., Huntington's disease.
• METHODS AND COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS
  申请人：Rubin Lee

  公开号：US20120010178A1

  公开（公告）日：2012-01-12

  Methods, compounds and compositions for promoting motor neuron survival and the treatment of a neurodegenerative disorders such as Spinal Muscular Atrophy (SMA) are described herein.
• US6268391B1
  申请人：——

  公开号：US6268391B1

  公开（公告）日：2001-07-31
• [EN] METHODS AND COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS<br/>[FR] PROCÉDÉS ET COMPOSÉS POUR LE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS
  申请人：HARVARD COLLEGE

  公开号：WO2010048273A2

  公开（公告）日：2010-04-29

  Methods, compounds and compositions for promoting motor neuron survival and the treatment of a neurodegenerative disorders such as Spinal Muscular Atrophy (SMA) are described herein.