3-chlorocarbonyloxy-1,1-dioxo-tetrahydro-1λ6-thiophene | 77691-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: 3-chlorocarbonyloxy-1,1-dioxo-tetrahydro-1λ6-thiophene
• 英文别名: (1,1-Dioxothiolan-3-yl) carbonochloridate
• CAS: 77691-76-0
• 化学式: C₅H₇ClO₄S
• mdl: MFCD00456631
• 分子量: 198.627
• InChiKey: WQTYQJIDLYKIAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-chlorocarbonyloxy-1,1-dioxo-tetrahydro-1λ6-thiophene 以78%的产率得到
  参考文献：
  名称：

  PARXOMENKO P. I., UKR. XIM. ZH., 1980, 46, HO 12, 1294-1301

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-二氧代-3-羟基-四氢噻吩 、 光气 生成 3-chlorocarbonyloxy-1,1-dioxo-tetrahydro-1λ6-thiophene
  参考文献：
  名称：

  PARXOMENKO P. I., UKR. XIM. ZH., 1980, 46, HO 12, 1294-1301

  摘要：

  DOI：

文献信息

• INHIBITORS OF FLAVIVIRIDAE VIRUSES
  申请人：CANALES Eda

  公开号：US20110178058A1

  公开（公告）日：2011-07-21

  Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

  提供的是I式化合物： 及其药用可接受的盐和酯。所提供的化合物、组合物和方法对于治疗黄病毒科病毒感染，特别是丙型肝炎感染，是有用的。
• Quinolone-3-diarylethers
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US10584098B2

  公开（公告）日：2020-03-10

  Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.

  所公开的是 ELQ-300 的衍生物化合物，其中包括位于第 4 位的酯。与 ELQ-300 相比，这些化合物具有更强的特性。还公开了包含这些化合物的药物组合物，以及治疗和预防疟疾感染的方法，其中包括给受试者施用药物组合物。
• QUINOLONE-3-DIARYLETHERS
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US20170022164A1

  公开（公告）日：2017-01-26

  Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.
• Method of Treating or Inhibiting Malaria
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US20200157053A1

  公开（公告）日：2020-05-21

  Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.