Bis(1,1-dioxidotetrahydrothiophen-3-yl) carbonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: Bis(1,1-dioxidotetrahydrothiophen-3-yl) carbonate
• 英文别名: bis(1,1-dioxothiolan-3-yl) carbonate
• 化学式: C₉H₁₄O₇S₂
• 分子量: 298.3
• InChiKey: ZNQHWEDDOLROQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-chlorocarbonyloxy-1,1-dioxo-tetrahydro-1λ6-thiophene 、 1,1-二氧代-3-羟基-四氢噻吩 、 三乙胺 以15%的产率得到
  参考文献：
  名称：

  PARXOMENKO P. I., UKR. XIM. ZH., 1980, 46, HO 12, 1294-1301

  摘要：

  DOI：

文献信息

• [EN] QUINOLONE-3-DIARYLETHERS<br/>[FR] QUINOLONE-3-DIARYLÉTHERS
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2017015360A1

  公开（公告）日：2017-01-26

  Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.

  揭示了ELQ-300的衍生化合物，其中在位置4处包含酯基。这些化合物相对于ELQ-300具有增强的性质。还揭示了包括这些化合物的药物组合物以及治疗和预防涉及向受试者施用这些药物组合物的疟疾感染的方法。
• Quinolone-3-diarylethers
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US10584098B2

  公开（公告）日：2020-03-10

  Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.

  所公开的是 ELQ-300 的衍生物化合物，其中包括位于第 4 位的酯。与 ELQ-300 相比，这些化合物具有更强的特性。还公开了包含这些化合物的药物组合物，以及治疗和预防疟疾感染的方法，其中包括给受试者施用药物组合物。
• QUINOLONE-3-DIARYLETHERS
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US20170022164A1

  公开（公告）日：2017-01-26

  Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.
• Method of Treating or Inhibiting Malaria
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US20200157053A1

  公开（公告）日：2020-05-21

  Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.
• PARXOMENKO P. I., UKR. XIM. ZH., 1980, 46, HO 12, 1294-1301
  作者：PARXOMENKO P. I.

  DOI：——

  日期：——