2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[hydroxy(phenylmethoxy)phosphoryl]oxypropanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[hydroxy(phenylmethoxy)phosphoryl]oxypropanoic acid
• 化学式: C₂₅H₂₄NO₈P
• 分子量: 497.4
• InChiKey: ZBPUWGDUVAAWJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• PHOSPHOLINKED DYE ANALOGS WITH AN AMINO ACID LINKER
  申请人：Shen Gene

  公开号：US20120052507A1

  公开（公告）日：2012-03-01

  In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including muliple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

  在各种实施方式中，本发明提供了通过氨基酸或肽连接剂与另一物种相连的荧光染料。在一个示例实施方式中，染料通过氨基酸或肽连接剂与聚磷酸核酸相连。这些共轭物在单分子DNA测序和其他应用中有用。在各种实施方式中，染料部分是一种靛烷染料。高度带电的靛烷染料，例如包括多个磺酸盐，烷基磺酸盐，羧酸盐和/或烷基羧酸盐部分的靛烷染料，是本发明化合物中使用的靛烷染料的示例。
• Phospholinked Dye Analogs with an Amino Acid Linker
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20150197794A1

  公开（公告）日：2015-07-16

  In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

  在各种实施方式中，本发明提供了通过氨基酸或肽连接剂与另一物种连接的荧光染料。在一个示例实施方式中，该染料通过氨基酸或肽连接剂与多聚磷酸核酸连接。这些结合物可用于单分子DNA测序和其他应用。在各种实施方式中，染料部分是一种靛蓝染料。高度带电的靛蓝染料，例如包括多个磺酸盐，烷基磺酸盐，羧酸盐和/或烷基羧酸盐基团的靛蓝染料，是本发明化合物中使用的靛蓝染料的例子。
• SINGLE MOLECULE SEQUENCING IDENTIFICATION OF POST-TRANSLATIONAL MODIFICATIONS ON PROTEINS
  申请人：Board of Regents, The University of Texas System

  公开号：EP3827093A1

  公开（公告）日：2021-06-02
• COATING FOR METAL NANOPARTICLES
  申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：US20180289843A1

  公开（公告）日：2018-10-11

  The invention relates to a ligand compound having a structure A-B-C, wherein (a) A represents a mono- or polyphosphorylated amino acid linked to part B by its amino group to form an amide bond; B represents (i) a carboxylic acid, and (ii) an amino acid or peptidyl group of 2-10 amino acids, an alkyl or alkenyl group comprising 1-26 carbon atoms, a polyethylene glycol group comprising 1-26 carbon atoms or a combination thereof covalently linked to the carboxylic acid; and C represents a hydrophilic group covalently linked to the group of B (ii) or (b) A represents a mono-or polyphosphorylated amino acid linked to B by its carboxylic acid to form an amide bond; B represents an amino acid or peptidyl group of 2-10 amino acids, an amino substituted alkyl or alkenyl group comprising 1-26 carbon atoms, an amino substituted polyethylene glycol group comprising 1-26 carbon atoms or a combination thereof covalently linked to A by their amino group; C represents a hydrophilic group covalently linked to the group of B. The invention further relates to a coated metal nanoparticle such as super paramagnetic iron oxide nanoparticle (SPIONs) coated with a plurality of the aforementioned ligands and a method of producing thereof.
• US8993737B2
  申请人：——

  公开号：US8993737B2

  公开（公告）日：2015-03-31