N,N′-bis(dimethyldodecyl)-1,2-ethanediammoniumdibromide | 18464-56-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N′-bis(dimethyldodecyl)-1,2-ethanediammoniumdibromide
• 英文别名: 1,2-Ethanediaminium, N,N'-didodecyl-N,N,N',N'-tetramethyl-；dodecyl-[2-[dodecyl(dimethyl)azaniumyl]ethyl]-dimethylazanium
• CAS: 18464-56-7
• 化学式: C₃₀H₆₆N₂
• 分子量: 454.867
• InChiKey: UREFWTSIFLAPEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.5
• 重原子数：
  32
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  四甲基乙二胺 、 溴代十二烷 以 乙醇 为溶剂， 反应 48.0h， 生成 N,N′-bis(dimethyldodecyl)-1,2-ethanediammoniumdibromide
  参考文献：
  名称：

  Thermodynamics of Mixed Surfactant Solutions of N,N′-Bis(dimethyldodecyl)-1,2-ethanediammoniumdibromide with 1-Dodecyl-3-methylimidazolium Bromide

  摘要：

  Mixed surfactant solutions are studied to understand their synergistic effects. Here we report the micellization properties of mixed surfactant solutions of the gemini surfactant N,N'-bis(dimethyldodecyl)-1,2-ethanediammoniumdibromide (12-2-12) with the imidazolium ionic liquid 1-dodecyl-3-methylimidazolium bromide (C(12)mimBr) investigated by isothermal titration calorimetry (ITC), conductometry, fluorimetry, and dynamic light scattering (DLS). A two-parameter Margules model was successfully used to correlate the cmc values and calculate the compositions and activity coefficients of the two components in the mixed micelle phase for 12-2-12/C(12)mimBr aqueous solutions with different overall surfactant compositions. The dissociation degree of counterion, the thermodynamic quantities of micellization, and the excess thermodynamic quantities for the mixed micelle were calculated and discussed. The ITC experiment in the low overall surfactant composition region showed a second phase transition. A thermodynamic model was proposed to explore phase behaviors of two different types of micelle and their solution, which was further confirmed by fluorescence and DLS studies.

  DOI：

  10.1021/jp412640m

文献信息

• [EN] BISCATIONIC AND TRISCATIONIC AMPHILES AS ANTIMICROBIAL AGENTS<br/>[FR] COMPOSÉS AMPHIPHILES BISCATIONIQUES ET TRISCATIONIQUES UTILISÉS COMME AGENTS ANTIMICROBIENS
  申请人：UNIV TEMPLE

  公开号：WO2015069760A1

  公开（公告）日：2015-05-14

  The present disclosure provides an antimicrobial composition including a compound which is a biscationic or triscationic amphiphile, and the method of making such an antimicrobial composition, and the method of using such a compound or composition for antimicrobial use. The antimicrobial composition can include a compound having the formula (I) wherein R is a methylene group unsubstituted or optionally substituted, s is an integer in the range from 1 to 6, R1, R2, R3 or R4 is H or a C 1-4 alkyl unsubstituted or optionally substituted, X is a halogen, m and n are integers in the range from 5 to 25, and m is not equal to n. Alternatively, the antimicrobial composition can comprise a compound having the formula (III) or (IV) wherein R1, R2, R3, R4 R5, or R6 is H or a C1-4 alkyl unsubstituted or optionally substituted, X or Y is a halogen, and m and n are integers in the range from 5 to 25.

  本公开提供了一种抗微生物组合物，包括一种双阳离子或三阳离子两性分子，以及制备此类抗微生物组合物的方法，以及使用此类化合物或组合物进行抗微生物用途的方法。抗微生物组合物可以包括具有以下结构式(I)的化合物，其中R是未取代或可选择取代的亚甲基基团，s是在1到6范围内的整数，R1、R2、R3或R4是H或未取代或可选择取代的C1-4烷基，X是卤素，m和n是在5到25范围内的整数，且m不等于n。或者，抗微生物组合物可以包括具有以下结构式(III)或(IV)的化合物，其中R1、R2、R3、R4、R5或R6是H或未取代或可选择取代的C1-4烷基，X或Y是卤素，m和n是在5到25范围内的整数。
• Verfahren zur Stabilisierung und/oder Isolierung von Nukleinsäuren
  申请人：QIAGEN GmbH

  公开号：EP1031626B1

  公开（公告）日：2011-01-26
• Consumer Products
  申请人：The Procter & Gamble Company

  公开号：US20150313803A1

  公开（公告）日：2015-11-05

  A consumer product comprises: (a) a porous dissolvable solid structure, and (b) a hydrophobic coating comprising a benefit agent. The hydrophobic coating is applied to the porous dissolvable solid structure and the hydrophobic coating has a viscosity of less than 14.5 Pa·s. A method of forming an aqueous treatment liquor comprises the steps of: (a) providing a consumer product, (b) providing an aqueous solution, and (c) dissolving the consumer product in the aqueous solution to form an aqueous treatment liquor comprising a hydrophobic portion and an aqueous portion. The hydrophobic portion of the aqueous treatment liquor has a viscosity of less than about 14.5 Pa·s.
• POLYCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS
  申请人：TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20160262384A1

  公开（公告）日：2016-09-15

  The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula (I) or (II) R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 10 , or R 11 is H or a C 1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH 2 , —NHR′, —NR′ 2 , —N—C(0)R′, —N—C(0)CR′═CR′, —SH, —SR′, -0-C(0)R′, —C(0)R′, —CF 3 , —OCF 3 , halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R 7 , R 8 or R 9 is a C 1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH 2 , —NHR′, —NR′ 2 , —SH, —SR′, -0-C(0)R′, —C(0)R′, —CF 3 , and —OCF 3 . R′ is H or a C 1-4 alkyl. X or Y is a halogen, m and n are integers in the range from 1 to 25.
• BISCATIONIC AND TRISCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS
  申请人：Temple University of the Commonwealth System of Higher Education

  公开号：US20160278375A1

  公开（公告）日：2016-09-29

  The present disclosure provides an antimicrobial composition including a compound which is a biscationic or triscationic amphiphile, and the method of making such an antimicrobial composition, and the method of using such a compound or composition for antimicrobial use. The antimicrobial composition can include a compound having the formula (I) wherein R is a methylene group unsubstituted or optionally substituted, s is an integer in the range from 1 to 6, R 1 , R 2 , R 3 or R 4 is H or a C 1-4 alkyl unsubstituted or optionally substituted, X is a halogen, m and n are integers in the range from 5 to 25, and m is not equal to n. Alternatively, the antimicrobial composition can comprise a compound having the formula (III) or (IV) wherein R 1 , R 2 , R 3 , R 4 R 5 , or R 6 is H or a C 1-4 alkyl unsubstituted or optionally substituted, X or Y is a halogen, and m and n are integers in the range from 5 to 25.