ethyl 1-naphthylacetamidate hydrochloride | 43002-67-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ethyl 1-naphthylacetamidate hydrochloride
• 英文别名: ethyl 1-naphthyliminoacetate hydrochloride；ethyl 1-naphthylacetimidate hydrochloride；Ethyl 2-(naphthalen-1-yl)ethanecarboximidate hydrochloride；ethyl 2-naphthalen-1-ylethanimidate;hydrochloride
• CAS: 43002-67-1
• 化学式: C₁₄H₁₅NO*ClH
• 分子量: 249.74
• InChiKey: IIZZGEVZGWWEIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  33.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl 1-naphthylacetamidate hydrochloride 在 sodium hypochlorite 、 氨 、 lithium chloride 、 sodium chloride 作用下， 以 乙醇 、 正己烷 、 二甲基亚砜 为溶剂， 反应 1.0h， 生成 3-(1-naphthylmethyl)-3-chlorodiazirine
  参考文献：
  名称：

  Preparation and crystal structure of 3-(1-naphthylmethyl)-3-chlorodiazirine

  摘要：

  DOI：

  10.1021/jo00240a029
• 作为产物：
  描述：

  1-萘乙腈 、 乙醇 在 盐酸 作用下， 以 氯仿 为溶剂， 反应 48.0h， 生成 ethyl 1-naphthylacetamidate hydrochloride
  参考文献：
  名称：

  Preparation and crystal structure of 3-(1-naphthylmethyl)-3-chlorodiazirine

  摘要：

  DOI：

  10.1021/jo00240a029

文献信息

• Oxidative Rearrangement of 2-Substituted Oxazolines. A Novel Entry to 5,6-Dihydro-2<i>H</i>-1,4-oxazin-2-ones and Morpholin-2-ones
  作者：Cynthia M. Shafer、Tadeusz F. Molinski

  DOI：10.1021/jo952144f

  日期：1996.1.1

  A novel synthesis of 5,6-dihydro-2H-1,4-oxazin-2-ones by SeO2-promoted oxidative rearrangement of 2-alkyl- and 2-(arylmethyl)oxazolines is described. Yields are good to excellent; (up to 94%) with the highest yields obtained for 2-arylmethyl- and 2-neopentyl-substituted oxazolines. This reaction provides convenient access to novel 5-aryl-substituted dihydrooxazinones in high yield. The latter compounds are important ''chiral glycine'' synthons for asymmetric synthesis of a-amino acids. Since oxazolines are readily derived from carboxylic acids or their equivalents, this oxidative rearrangement constitutes an entry to synthesis of a-amino acids from carboxylic acids. A mechanism is proposed to account for the rearrangement involving a ''nitrilium to acylium'' 1,2-migration.
• Optically active derivatives of imidazolines. .alpha.-Adrenergic blocking properties
  作者：Fu-Lian Hsu、Akihiko Hamada、Mark E. Booher、H. Fuder、P. N. Patil、Duane D. Miller

  DOI：10.1021/jm00185a017

  日期：1980.11

  The synthesis and alpha-adrenergic blocking activity of a series of optically active 2,4-disubstituted imidazolines are presented. The substituted analogues of naphazoline, tolazoline, and clonidine possess moderate alpha-adrenergic blocking activity with -log KB values in the range from 4.77 to 6.57. The differences between the alpha-adrenergic blocking activity of the stereoisomers of the 2,4-disubstituted imidazolines were small or insignificant in the rabbit aortic tissue preparations.
• HSU F.-L.; HAMADA AKIHIKO; BOOHER M. E.; FUDER H.; PATIL P. N.; MILLER D.+, J. MED. CHEM., 1980, 23, NO 11, 1232-1235
  作者：HSU F.-L.、 HAMADA AKIHIKO、 BOOHER M. E.、 FUDER H.、 PATIL P. N.、 MILLER D.+

  DOI：——

  日期：——
• LINDEN, ANTHONY;CAMERON, T. STANLEY;LIU, MICHAEL T. H.;ANAND, SURINDER M., J. ORG. CHEM., 53,(1988) 1085-1087
  作者：LINDEN, ANTHONY、CAMERON, T. STANLEY、LIU, MICHAEL T. H.、ANAND, SURINDER M.

  DOI：——

  日期：——
• Preparation and crystal structure of 3-(1-naphthylmethyl)-3-chlorodiazirine
  作者：Anthony Linden、T. Stanley Cameron、Michael T. H. Liu、Surinder M. Anand

  DOI：10.1021/jo00240a029

  日期：1988.3