Methyl 3-(5-ethyl-2,4-dimethoxyphenyl)-2-naphthalen-1-yl-3-oxopropanoate | 926626-06-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: Methyl 3-(5-ethyl-2,4-dimethoxyphenyl)-2-naphthalen-1-yl-3-oxopropanoate
• CAS: 926626-06-4
• 化学式: C₂₄H₂₄O₅
• 分子量: 392.452
• InChiKey: JMBCTIUAPMFZAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 3-(5-ethyl-2,4-dimethoxyphenyl)-2-naphthalen-1-yl-3-oxopropanoate 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 6-Ethyl-4,7-dihydroxy-3-naphthalen-1-ylchromen-2-one
  参考文献：
  名称：

  WO2007/21966

  摘要：

  公开号：
• 作为产物：
  描述：

  methyl 2,4-dimethoxy-5-ethylbenzoate 、 1-萘乙酸甲酯 在 sodium methylate 作用下， 以29%的产率得到Methyl 3-(5-ethyl-2,4-dimethoxyphenyl)-2-naphthalen-1-yl-3-oxopropanoate
  参考文献：
  名称：

  WO2007/21966

  摘要：

  公开号：

文献信息

• Pyrazole compounds that modulate HSP90 activity
  申请人：Ying Weiwen

  公开号：US20070191445A1

  公开（公告）日：2007-08-16

  Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R 5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R 18 , defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R 3 . Substituent R 3 is defined herein.
• PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY
  申请人：Ying Weiwen

  公开号：US20100069442A1

  公开（公告）日：2010-03-18

  Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R 5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R 18 , defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R 3 . Substituent R 3 is defined herein.
• US7608635B2
  申请人：——

  公开号：US7608635B2

  公开（公告）日：2009-10-27
• US8329899B2
  申请人：——

  公开号：US8329899B2

  公开（公告）日：2012-12-11
• US8921407B2
  申请人：——

  公开号：US8921407B2

  公开（公告）日：2014-12-30