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1-Isopropoxy-7-methoxy-naphthalene-2-carboxylic acid (1H-tetrazol-5-yl)-amide | 117666-63-4

中文名称
——
中文别名
——
英文名称
1-Isopropoxy-7-methoxy-naphthalene-2-carboxylic acid (1H-tetrazol-5-yl)-amide
英文别名
7-methoxy-1-propan-2-yloxy-N-(2H-tetrazol-5-yl)naphthalene-2-carboxamide
1-Isopropoxy-7-methoxy-naphthalene-2-carboxylic acid (1H-tetrazol-5-yl)-amide化学式
CAS
117666-63-4
化学式
C16H17N5O3
mdl
——
分子量
327.343
InChiKey
GHCXQFKCXGJMBM-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.6
  • 重原子数:
    24
  • 可旋转键数:
    5
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.25
  • 拓扑面积:
    102
  • 氢给体数:
    2
  • 氢受体数:
    6

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为产物:
    参考文献:
    名称:
    Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents
    摘要:
    The synthesis and antiallergic activity of a series of novel benzothiophene-, benzofuran-, and naphthalenecarbox-amidotetrazoles are described. A number of the compounds inhibit the release of histamine from anti-IgE stimulated basophils obtained from allergic donors. Optimal inhibition is exhibited in benzothiophenes with a 3-alkoxy substituent in combination with a 5-methoxy, 6-methoxy, or a 5,6-dimethoxy group. Compounds 13c (CI-959) also inhibited respiratory burst of human neutrophils and the release of mediators from anti-IgE-stimulated human chopped lung.
    DOI:
    10.1021/jm00083a023
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文献信息

  • Novel naphthalene derivatives and antiallergy and anti-inflammatory pharmaceuticals
    申请人:WARNER-LAMBERT COMPANY
    公开号:EP0279466A2
    公开(公告)日:1988-08-24
    Novel naphthalene derivatives of the formula (I): having antiallergy and antiinflammatory activity.
    式 (I) 的新型萘衍生物: 具有抗过敏和抗炎活性。
  • US4767776A
    申请人:——
    公开号:US4767776A
    公开(公告)日:1988-08-30
  • Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents
    作者:David T. Connor、Wiaczeslaw A. Cetenko、Michael D. Mullican、Roderick J. Sorenson、Paul C. Unangst、Robert J. Weikert、Richard L. Adolphson、John A. Kennedy、David O. Thueson
    DOI:10.1021/jm00083a023
    日期:1992.3
    The synthesis and antiallergic activity of a series of novel benzothiophene-, benzofuran-, and naphthalenecarbox-amidotetrazoles are described. A number of the compounds inhibit the release of histamine from anti-IgE stimulated basophils obtained from allergic donors. Optimal inhibition is exhibited in benzothiophenes with a 3-alkoxy substituent in combination with a 5-methoxy, 6-methoxy, or a 5,6-dimethoxy group. Compounds 13c (CI-959) also inhibited respiratory burst of human neutrophils and the release of mediators from anti-IgE-stimulated human chopped lung.
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