(E)-N-diethyl-3-(2-chlorophenyl)-2-(phenyl)-prop-2-enamide | 1261237-38-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-N-diethyl-3-(2-chlorophenyl)-2-(phenyl)-prop-2-enamide
• 英文别名: (E)-N,N-diethyl-3-(2-chlorophenyl)-2-(phenyl)-prop-2-enamide；(E)-3-(2-chlorophenyl)-N,N-diethyl-2-phenylprop-2-enamide
• CAS: 1261237-38-0
• 化学式: C₁₉H₂₀ClNO
• 分子量: 313.827
• InChiKey: QDASWNLAOGAPCX-SAPNQHFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯乙酸 在 氯化亚砜 、 乙酸酐 、 三乙胺 作用下， 以 苯 为溶剂， 反应 20.0h， 生成 (E)-N-diethyl-3-(2-chlorophenyl)-2-(phenyl)-prop-2-enamide
  参考文献：
  名称：

  Synthesis and biological evaluation of some stilbene derivatives

  摘要：

  Several trans and cis stilbenes with substitution on the olefinic bridge were synthesized and characterized by IR, NMR and mass spectroscopy in an effort to obtain substances that could be more readily formulated. All the synthesized compounds were screened against Molt4/C8, CEM and L1210 cell lines. None of these compounds were endowed with pronounced cytostatic activity. However, Schiff derivatives emerged as cytostatic agents (IC(50): 0.77-10 mu g/ml) that deserve further investigation.

  DOI：

  10.1007/s00044-010-9484-1

文献信息

• Synthesis and biological evaluation of some stilbene derivatives
  作者：Subhas Somalingappa Karki、Santosh Ramarao Bhutle、Subhas Sahoo、Ratnakar Reddy、Jan Balzarini、Erik De Clercq、Satyanarayana Y. Darji

  DOI：10.1007/s00044-010-9484-1

  日期：2011.11

  Several trans and cis stilbenes with substitution on the olefinic bridge were synthesized and characterized by IR, NMR and mass spectroscopy in an effort to obtain substances that could be more readily formulated. All the synthesized compounds were screened against Molt4/C8, CEM and L1210 cell lines. None of these compounds were endowed with pronounced cytostatic activity. However, Schiff derivatives emerged as cytostatic agents (IC(50): 0.77-10 mu g/ml) that deserve further investigation.