(2-Ethyl-5,6-dimethoxy-1H-inden-1-yl)-dimethyl-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: (2-Ethyl-5,6-dimethoxy-1H-inden-1-yl)-dimethyl-amine
• 英文别名: 2-ethyl-5,6-dimethoxy-N,N-dimethyl-1H-inden-1-amine
• 化学式: C₁₅H₂₁NO₂
• 分子量: 247.337
• InChiKey: DLGWJPIXRALJFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(3',4'-Dimethoxyphenyl)butanol 在 对甲苯磺酸 、 三氯氧磷 作用下， 以 苯 为溶剂， 生成 (2-Ethyl-5,6-dimethoxy-1H-inden-1-yl)-dimethyl-amine
  参考文献：
  名称：

  Pharmacology on rat ileum of certain 2-substituted 3-(dimethylamino)-5,6-dimethoxyindenes related to 5,6-(methylendioxy)indene calcium antagonist

  摘要：

  Whereas the 2-propyl- and 2-butyl-5,6-(methylenedioxy)indene calcium antagonists reversed the spasmogenic action of several agonists including PGF2alpha and acetylcholine at 5 X 10(-5) to 10(-4) M on the rat ileum, the corresponding 5,6-dimethoxy analogues exhibited spasmogenic activity at higher concentration (10(-4)-10(-3) M) and exhibited neither spasmogenic nor spasmolytic activity at lower (10(-6)-10(-5) M) concentration. The results are compared to the methyl and 2-ethyl analogues. At 10(-4) M only the butyl analogue was capable of moderate antagonism of acetylcholine and at 10(-3) M all four analogues were capable of moderately antagonizing the actions of acetylcholine.

  DOI：

  10.1021/jm00210a028

文献信息

• Pharmacology on rat ileum of certain 2-substituted 3-(dimethylamino)-5,6-dimethoxyindenes related to 5,6-(methylendioxy)indene calcium antagonist
  作者：Donald T. Witiak、Sunil V. Kakodkar、George E. Brunst、John R. Baldwin、Ralf G. Rahwan

  DOI：10.1021/jm00210a028

  日期：1978.12

  Whereas the 2-propyl- and 2-butyl-5,6-(methylenedioxy)indene calcium antagonists reversed the spasmogenic action of several agonists including PGF2alpha and acetylcholine at 5 X 10(-5) to 10(-4) M on the rat ileum, the corresponding 5,6-dimethoxy analogues exhibited spasmogenic activity at higher concentration (10(-4)-10(-3) M) and exhibited neither spasmogenic nor spasmolytic activity at lower (10(-6)-10(-5) M) concentration. The results are compared to the methyl and 2-ethyl analogues. At 10(-4) M only the butyl analogue was capable of moderate antagonism of acetylcholine and at 10(-3) M all four analogues were capable of moderately antagonizing the actions of acetylcholine.