1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(methylaminomethoxymethyl)oxolan-2-yl]-2-sulfanylidenepyrimidin-4-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(methylaminomethoxymethyl)oxolan-2-yl]-2-sulfanylidenepyrimidin-4-one
• 化学式: C₁₁H₁₇N₃O₅S
• 分子量: 303.34
• InChiKey: IPIZCEIUSCGZLZ-PEBGCTIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  135
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Antiviral compounds and methods of use thereof
  申请人：Trana Discovery, Inc.

  公开号：US10098887B2

  公开（公告）日：2018-10-16

  Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.

  本研究公开了逆转录病毒传播抑制剂、使用这些抑制剂治疗和预防逆转录病毒感染的方法以及包括这些抑制剂的药物组合物。
• NUCLEIC ACID VACCINES FOR VARICELLA ZOSTER VIRUS (VZV)
  申请人：ModernaTX, Inc.

  公开号：EP3364980A1

  公开（公告）日：2018-08-29
• MODIFIED MRNA VACCINES ENCODING HERPES SIMPLEX VIRUS GLYCOPROTEINS AND USES THEREOF
  申请人：The Trustees of The University of Pennsylvania

  公开号：EP3668520A1

  公开（公告）日：2020-06-24
• ANTIVIRAL COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Trana Discovery, Inc.

  公开号：US20160129006A1

  公开（公告）日：2016-05-12

  Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.
• INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF METHIONYL-TRNA SYNTHETASES
  申请人：aTyr Pharma, Inc.

  公开号：US20200140571A1

  公开（公告）日：2020-05-07

  Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.