2,4-dioxo-1,4-dihydro-2H-benz[d][1,3]oxazine-5-carboxylic acid methyl ester | 412341-94-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 2,4-dioxo-1,4-dihydro-2H-benz[d][1,3]oxazine-5-carboxylic acid methyl ester
• 英文别名: 2,4-Dioxo-1,4-dihydro-2H-benz[d][1,3]oxazin-5-carbonsaeure-methylester；2,4-dioxo-1H-[3,1]benzoxazine-5-carboxylic acid methyl ester；methyl 2,4-dioxo-1H-3,1-benzoxazine-5-carboxylate
• CAS: 412341-94-7
• 化学式: C₁₀H₇NO₅
• 分子量: 221.169
• InChiKey: OJQSFEZOFVXXMJ-UHFFFAOYSA-N

物化性质

• 熔点：
  188-190 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• 密度：
  1.434±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-dioxo-1,4-dihydro-2H-benz[d][1,3]oxazine-5-carboxylic acid methyl ester 在 氢氧化钾 、 乙醚 作用下， 生成 1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-5-carboxylic acid
  参考文献：
  名称：

  Quinazolines. IX. A Study of an Unusual Reaction of 5-Diazoacetyl-1,3-dimethyl-2,4-quinazolinedione¹

  摘要：

  DOI：

  10.1021/ja01167a010
• 作为产物：
  描述：

  光气 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2,4-dioxo-1,4-dihydro-2H-benz[d][1,3]oxazine-5-carboxylic acid methyl ester
  参考文献：
  名称：

  Quinazolines. IX. A Study of an Unusual Reaction of 5-Diazoacetyl-1,3-dimethyl-2,4-quinazolinedione¹

  摘要：

  DOI：

  10.1021/ja01167a010

文献信息

• Piperidine derivatives having ccr3 antagonism
  申请人：Matsumoto Yoshiyuki

  公开号：US20070032525A1

  公开（公告）日：2007-02-08

  The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides compounds represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C 1 -C 6 alkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis.

  本发明提供了具有抑制CCR3配体结合到靶细胞CCR3的活性的低分子化合物，即CCR3拮抗剂。本发明还提供了由下式（I）表示的化合物，其药学上可接受的酸加合物或药学上可接受的C1-C6烷基加合物，以及包含它们作为有效成分的制药组合物，用于治疗或预防与CCR3相关的疾病，例如哮喘和过敏性鼻炎。
• PIPERIDINE DERIVATIVES HAVING CCR3 ANTAGONISM
  申请人：TEIJIN LIMITED

  公开号：EP1502916A1

  公开（公告）日：2005-02-02

  The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides compounds represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C1-C6 alkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis.

  本发明提供了具有抑制 CCR3 配体与靶细胞上 CCR3 结合活性的低分子化合物，即 CCR3 拮抗剂。本发明还提供了下式(I)代表的化合物、其药学上可接受的酸加合物或其药学上可接受的C1-C6烷基加合物，以及包含它们作为有效成分的药物组合物，这些化合物可用于治疗或预防与CCR3相关的疾病，如哮喘和过敏性鼻炎。
• Polymer compositions and use of these polymer compositions as dispersants
  申请人：BASF SE

  公开号：US10131750B2

  公开（公告）日：2018-11-20

  A polymer composition, obtainable by reacting a) a polymer P1 having at least one functional group of the formula (I) and a polymer backbone B, and b) a polymer P2 which is a polyolefine succinic anhydride:

  一种聚合物组合物，可通过反应 a) 具有至少一个式（I）官能团的聚合物 P1 和聚合物骨架 B，以及 b) 聚烯烃琥珀酸酐聚合物 P2 而获得：
• Polymer compositions and use of these polymer compositions as viscosity modifiers
  申请人：BASF SE

  公开号：US10730967B2

  公开（公告）日：2020-08-04

  The present invention relates to novel polymer compositions, to a process for their manufacturing, to the use of said polymer compositions for modifying the viscosity of aqueous compositions, and to water-borne coating compositions containing the novel polymer compositions as thickeners. The polymer compositions comprise a polymer material which is obtainable by reacting: a) a polymer P1 having at least one functional group of the formula (I), where k is an integer from 0 to 4; n is 0 or 1 p is an integer from 1 to 10, the number average of p being from 1.5 to 10; Q is a divalent moiety selected from the group consisting of —O— and —NH—; P is a p-valent hydrophilic neutral polymer radical; and R1 is as defined in the claims; with b) a succinic anhydride of the formula (II) where R is C4-C24-alkyl or C4-C24-alkenyl.

  本发明涉及新型聚合物组合物、其制造工艺、使用所述聚合物组合物调节水性组合物粘度的 方法，以及含有新型聚合物组合物作为增稠剂的水性涂料组合物。所述聚合物组合物包括一种聚合物材料，该聚合物材料可通过以下反应获得： a) 具有至少一个式（I）官能团的聚合物 P1，其中 k 是 0 至 4 的整数；n 是 0 或 1 p 是 1 至 10 的整数，p 的平均数为 1.5至10；Q是选自-O-和-NH-组成的组的二价分子；P是p价亲水性中性聚合物基团；R1如权利要求中所定义；b)式(II)的琥珀酸酐，其中R是C4-C24-烷基或C4-C24-烯基。
• NOVEL POLYMER DISPERSANTS
  申请人：BASF SE

  公开号：EP2817358A1

  公开（公告）日：2014-12-31