2,7-naphthyridin-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,7-naphthyridin-3-amine
• 英文别名: 2,7-Naphthyridin-3-amine
• 化学式: C₈H₇N₃
• 分子量: 145.164
• InChiKey: GGWLUFMQZSOAAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,7-naphthyridin-3-amine 在 三乙烯二胺 、 bis-triphenylphosphine-palladium(II) chloride 、 N-碘代丁二酰亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  [EN] METHODS FOR TREATING NEUROLOGICAL DISORDERS
  [FR] MÉTHODES DE TRAITEMENT DE TROUBLES NEUROLOGIQUES

  摘要：

  This disclosure provides compounds and pharmaceutically acceptable salts thereof, that inhibit Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). These chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) DYRK1A activation contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., a neurological disorder) in a subject (e.g., a human). This disclosure also provides compositions containing the same as well as methods of using and making the same.

  公开号：

  WO2023107723A2
• 作为产物：
  描述：

  tert-butyl (2,7-naphthyridin-3-yl)carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 2,7-naphthyridin-3-amine
  参考文献：
  名称：

  [EN] METHODS FOR TREATING NEUROLOGICAL DISORDERS
  [FR] MÉTHODES DE TRAITEMENT DE TROUBLES NEUROLOGIQUES

  摘要：

  This disclosure provides compounds and pharmaceutically acceptable salts thereof, that inhibit Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). These chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) DYRK1A activation contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., a neurological disorder) in a subject (e.g., a human). This disclosure also provides compositions containing the same as well as methods of using and making the same.

  公开号：

  WO2023107723A2

文献信息

• [EN] ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS<br/>[FR] AMÉLIORATION DE LA POLYMÉRISATION D'ACIDES NUCLÉIQUES PAR DES COMPOSÉS AROMATIQUES
  申请人：STRATOS GENOMICS INC

  公开号：WO2019135975A1

  公开（公告）日：2019-07-11

  The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.

  本发明涉及化合物、方法和组合物，用于改善核酸聚合，包括通过体外引物延伸的DNA复制，以生成例如纳米孔单分子测序的聚合物的方法。提供一种含有聚合增强物的核酸聚合酶反应组合物，其允许使用核苷酸类似物增强DNA聚合酶活性，从而改善引物延伸产物的长度，以用于测序应用。
• ORGANIC LIGHT-EMITTING DEVICE
  申请人：Samsung Display Co., Ltd.

  公开号：EP3185331A1

  公开（公告）日：2017-06-28

  An organic light-emitting device comprising: a first electrode; a second electrode facing the first electrode; an emission layer between the first electrode and the second electrode; a hole transport region between the first electrode and the emission layer; and an electron transport region between the emission layer and the second electrode, wherein at least one selected from the hole transport region and the emission layer comprises a first compound represented by Formula 1A or 1B, and at least one selected from the hole transport region and the electron transport region comprises a second compound represented by Formula 2:

  一种有机发光器件，包括：第一电极；面向第一电极的第二电极；位于第一电极和第二电极之间的发射层；位于第一电极和发射层之间的空穴传输区域；以及位于发射层和第二电极之间的电子传输区域，其中至少一种选自空穴传输区域和发射层的化合物由式 1A 或 1B 表示的第一种化合物组成，而至少一种选自空穴传输区域和电子传输区域的化合物由式 2 表示的第二种化合物组成：
• AMINE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：EP3444241A1

  公开（公告）日：2019-02-20

  An amine-based compound represented by Formula 1, in which one of R1 to R10 is a group represented by Formula 2, and an organic light-emitting device including the same are provided: When the amine-based compound is included in an organic light-emitting device as a hole transport material, the device may exhibit excellent I-V-L characteristics, including a low driving voltage, improved efficiency, and improved lifespan.

  提供了一种由式 1 表示的胺基化合物（其中 R1 至 R10 中的一个是由式 2 表示的基团）以及包括该化合物的有机发光器件： 当胺基化合物作为空穴传输材料被包含在有机发光器件中时，该器件可表现出优异的 I-V-L 特性，包括低驱动电压、更高的效率和更长的寿命。
• DIAMINE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：EP3561894A1

  公开（公告）日：2019-10-30

  Provided are a diamine compound including a naphthyl-phenyl linker and a 2-carbazolyl group and an organic light-emitting device including the same. The organic light-emitting device includes: a first electrode; a second electrode; and an organic layer between the first electrode and the second electrode and including an emission layer, wherein the organic layer includes the diamine compound including the naphthyl-phenyl linker and the 2-carbazolyl group.

  本发明提供了一种包括萘基-苯基连接体和 2-咔唑基团的二胺化合物，以及一种包括该二胺化合物的有机发光器件。有机发光器件包括：第一电极；第二电极；以及位于第一电极和第二电极之间并包括发射层的有机层，其中有机层包括二胺化合物，该二胺化合物包括萘基-苯基连接体和 2-咔唑基团。
• CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：EP3428149B1

  公开（公告）日：2021-07-28