2-[[(2R)-2,3-bis(hexadec-1-enoxy)propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-[[(2R)-2,3-bis(hexadec-1-enoxy)propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C40H81NO6P+
• 分子量: 703.0
• InChiKey: VKQPPRFFLYKMPX-RRHRGVEJSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  14.6
• 重原子数：
  48
• 可旋转键数：
  38
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• LIPOSOMAL COMPOSITIONS WITH LIGHT ILLUMINATION-INDUCED DRUG RELEASE
  申请人：Creighton University

  公开号：US20180243419A1

  公开（公告）日：2018-08-30

  Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes containing small molecules and oppositely charged conjugates of a peptide with a photosensitizer attached to one end of peptide chain, providing binding to liposomes and their permeabilization upon light illumination.

  这里提供了一种小分子递送系统，其基于带电脂质体和带有光敏剂的肽共轭物的二元组合，通过光照诱导小分子释放，提供与脂质体的结合和光照下的渗透性，从而实现小分子的释放。
• Liposomal compositions with light illumination-induced drug release
  申请人：Creighton University

  公开号：US11154619B2

  公开（公告）日：2021-10-26

  Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes containing small molecules and oppositely charged conjugates of a peptide with a photosensitizer attached to one end of peptide chain, providing binding to liposomes and their permeabilization upon light illumination.

  本文提供了一种具有光照诱导小分子释放功能的小分子给药系统，该系统基于含有小分子的带电脂质体和肽的带相反电荷的共轭物的二元组合，肽链的一端附有光敏剂，在光照下可与脂质体结合并使其通透。