(3S)-4-[[(4R,7S,10R)-7-benzyl-4-(carboxymethylcarbamoyl)-6,9-dioxo-1,2-dithia-5,8-diazacycloundec-10-yl]amino]-3-[[2-[[(2S)-5-carbamimidamido-2-[[(3R,6S,9S)-6-(carboxymethyl)-9-[4-[6-[2-[5-(1-ethyl-3,3-dimethyl-5-sulfoindol-2-ylidene)penta-1,3-dienyl]-3,3-dimethyl-5-sulfoindol-1-ium-1-yl]hexanoylamino]butyl]-5,8,11-trioxo-1-thia-4,7,10-triazacyclododecane-3-carbonyl]amino]pentanoyl]amino]acetyl]amino]-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: (3S)-4-[[(4R,7S,10R)-7-benzyl-4-(carboxymethylcarbamoyl)-6,9-dioxo-1,2-dithia-5,8-diazacycloundec-10-yl]amino]-3-[[2-[[(2S)-5-carbamimidamido-2-[[(3R,6S,9S)-6-(carboxymethyl)-9-[4-[6-[2-[5-(1-ethyl-3,3-dimethyl-5-sulfoindol-2-ylidene)penta-1,3-dienyl]-3,3-dimethyl-5-sulfoindol-1-ium-1-yl]hexanoylamino]butyl]-5,8,11-trioxo-1-thia-4,7,10-triazacyclododecane-3-carbonyl]amino]pentanoyl]amino]acetyl]amino]-4-oxobutanoic acid
• 化学式: C77H103N16O23S5+
• 分子量: 1781.1
• InChiKey: UXYRXPZPEHKVIH-MENCHSDRSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  121
• 可旋转键数：
  39
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  702
• 氢给体数：
  19
• 氢受体数：
  28

文献信息

• Optical Imaging
  申请人：Cuthbertson Alan

  公开号：US20090232741A1

  公开（公告）日：2009-09-17

  This invention relates to a method for imaging of wet age-related macular degeneration (AMD) using a contrast agent comprising a vector attached to an optical imaging reporter, wherein the vector has affinity for receptors associated with angiogenesis. The invention further provides such methods for monitoring the effect of treatment of AMD.

  本发明涉及一种使用包含附着于光学成像报告物的向量的对比剂的方法，其中该向量具有与血管生成相关的受体亲和力，用于成像湿性年龄相关性黄斑变性（AMD）。本发明还提供了这种方法，用于监测AMD的治疗效果。
• Peptide Based-Compounds
  申请人：Cuthbertson Alan

  公开号：US20080095715A1

  公开（公告）日：2008-04-24

  The invention relates to new peptide-based compounds and their use in diagnostic optical imaging techniques. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labelled with at least one cyanine dye reporter and may be used as contrast agents in optical imaging in diagnosis of angiogenesis-related diseases.
• US7897142B2
  申请人：——

  公开号：US7897142B2

  公开（公告）日：2011-03-01