1-[6-Amino-9-methyl-8-(triazol-2-yl)purin-2-yl]butan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1-[6-Amino-9-methyl-8-(triazol-2-yl)purin-2-yl]butan-2-one
• 英文别名: 1-[6-amino-9-methyl-8-(triazol-2-yl)purin-2-yl]butan-2-one
• 化学式: C₁₂H₁₄N₈O
• 分子量: 286.29
• InChiKey: YVIPZNHRQMRADV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• ADENOSINE RECEPTOR MODULATORS FOR THE TREATMENT OF CIRCADIAN RHYTHM DISORDERS
  申请人：Oxford University Innovation Limited

  公开号：EP3280414A1

  公开（公告）日：2018-02-14
• Adenosine Receptor Modulators for the Treatment of Circadian Rhythm Disorders
  申请人：OXFORD UNIVERSITY INNOVATION LIMITED

  公开号：US20190111069A1

  公开（公告）日：2019-04-18

  The present invention relates to the use of adenosine receptor modulators to affect the circadian rhythm, in particular, to the use of such modulators for the treatment of circadian rhythm disorders. In particular, the invention relates to a composition comprising at least one selective adenosine receptor modulator, wherein said composition modulates two or three, but not all of adenosine receptor subtypes A 1 , A 2A , A 2B and/or A 3 for use in the treatment of circadian rhythm disorders or for modulating a biological clock.
• [EN] ADENOSINE RECEPTOR MODULATORS FOR THE TREATMENT OF CIRCADIAN RHYTHM DISORDERS<br/>[FR] MODULATEURS DU RÉCEPTEUR DE L'ADÉNOSINE DESTINÉS AU TRAITEMENT DE TROUBLES DU RYTHME CIRCADIEN
  申请人：UNIV OXFORD INNOVATION LTD

  公开号：WO2017178820A1

  公开（公告）日：2017-10-19

  The present invention relates to the use of adenosine receptor modulators to affect the circadian rhythm, in particular, to the use of such modulators for the treatment of circadian rhythm disorders. In particular, the invention relates to a com position com prising at least one selective adenosine receptor modulator, wherein said composition modulates two or three, but not al l of adenosine receptor subtypes A1, A2A, A2B and/or A3 for use in the treatment of circadian rhythm disorders or for modulating a biological clock.