6-Methylidene-2,3,3a,6a-tetrahydrofuro[3,2-b]furan

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: 6-Methylidene-2,3,3a,6a-tetrahydrofuro[3,2-b]furan
• 英文别名: 6-methylidene-2,3,3a,6a-tetrahydrofuro[3,2-b]furan
• 化学式: C₇H₁₀O₂
• 分子量: 126.15
• InChiKey: VOUFOCLENHMDIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 5-PHENYLAZAINDOLE DERIVATIVE HAVING AMPK ACTIVATING EFFECT
  申请人：Shionogi & Co., Ltd

  公开号：EP3421467A1

  公开（公告）日：2019-01-02

  Provided is a compound which is useful as an AMPK activator. A compound represented by formula: wherein X is substituted or unsubstituted monocyclic heterocyclyl or the like; ring A is substituted aryl, substituted heteroaryl, substituted cycloalkyl, substituted cycloalkenyl, or substituted heterocyclyl, wherein the ring A may further have a substituent(s) other than Y; Y is halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; R4, R5, R6 and R7 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted sulfamoyl, or substituted or unsubstituted amino; R8 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like; and R9 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like, or its pharmaceutically acceptable salt.

  本文提供了一种可用作 AMPK 激活剂的化合物。一种由式表示的化合物： 其中 X 是取代或未取代的单环杂环基或类似物； 环 A 是取代的芳基、取代的杂芳基、取代的环烷基、取代的环烯基或取代的杂环烯基，其中环 A 可进一步具有除 Y 以外的取代基； Y 是卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基或类似物； R4、R5、R6 和 R7 各自独立地是氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的烷氧基、取代或未取代的烷硫基、取代或未取代的烷磺酰基、取代或未取代的酰基、取代或未取代的氨基甲酰基、取代或未取代的氨基磺酰基或取代或未取代的氨基； R8 是氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基、取代或未 取代的烯基、取代或未取代的炔基或类似物；以及 R9 是氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基或类似物、 或其药学上可接受的盐。