3-phenyl-5-p-tolyl-4,5-dihydroindeno[1,2-c][1,2]diazepin-6(1H)-one | 1390627-13-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 3-phenyl-5-p-tolyl-4,5-dihydroindeno[1,2-c][1,2]diazepin-6(1H)-one
• 英文别名: 5-(4-methylphenyl)-3-phenyl-4,5-dihydro-1H-indeno[1,2-c]diazepin-6-one
• CAS: 1390627-13-0
• 化学式: C₂₅H₂₀N₂O
• 分子量: 364.447
• InChiKey: JGZACQFPVXFDGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(3-oxo-3-phenyl-1-p-tolylpropyl)-2H-indene-1,3-dione 在 一水合肼 作用下， 反应 0.33h， 以94%的产率得到3-phenyl-5-p-tolyl-4,5-dihydroindeno[1,2-c][1,2]diazepin-6(1H)-one
  参考文献：
  名称：

  A Novel and Highly Efficient Protocol for the Synthesis of Chalcone Based 1,2-Diazepine and 1,2-Oxazepine Derivatives

  摘要：

  A novel and highly efficient protocol is described for the synthesis of chalcone based 1,2-diazepine and I,2-oxazepine derivatives. Under neat condition, the mixing and grinding of 1,5-diketones and hydrazine gave the cyclocondensation products in quantitative yields within 10-20 min at room temperature. Similarly, novel chalcone based 1,2-oxazepines were synthesized in excellent yields (85-88%) in 2-3 h at refluxed by the condensation of 1,5-diktones and hydroxylamine hydrochloride in water-ethanolic base.

  DOI：

  10.3987/com-12-12444